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Phase 1: Human Biology and Disease

The block-based curriculum for years one and two has been designed to increase integration of normal human biology with disease processes and clinical skills from the first week of medical school onward. Basic science is taught in the context of its application with planned reiteration. Instruction is coordinated throughout sequentially-taught blocks.

Characteristics of Phase 1
  • Instruction is driven by cases explored in small group, laboratories, conferences, clinical skills workshops, and independent study settings accompanied by 10 hours of lecture a week.
  • Contact time is limited to 24 hours a week to allow time for independent study and electives.
  • All but one of the thematic blocks is taught in two "passes". There is planned redundancy as well as progressive depth and expectations of competency. Most blocks are 8 weeks in length.
  • Curricular Threads are woven into the fabric of each block, and include
    • Doctoring principles and clinical skills
    • Anatomy, histopathology and embryology
    • Genetics and genomics
    • Population medicine, informatics and clinical reasoning
    • Pharmacology
  • Special issues are addressed across the curriculum in all four years:
  • Progress through this curriculum is evaluated on a pass/fail basis. Regular assessments during each block allow students to track their understanding and adjust study practices or emphasis as indicated.
Human Biology & Disease: The New Integrated Curriculum

Year 1


Block 1: HB&D 401 Foundations of Medicine I

Pathologic processes, genetics, molecular and cellular biology, basic immunology, and critical appraisal.
Thomas Drake (Tdrake@mednet.ucla.edu)
Sally Krasne (Skrasne@mednet.ucla.edu)

Block 2: HB&D 402 Cardiovascular, Renal, & Respiratory Medicine I

Anatomy, pathology, physiology, biochemistry, genetics, clinical skills, imaging, and selected pathophysiologic mechanisms of these organ systems.
Jan Tillisch (Jtillisch@mednet.ucla.edu)
John Tormey (Jtormey@mednet.ucla.edu)

Block 3: HB&D 403 Gastrointestinal, Endocrine, & Reproductive Medicine I

Anatomy, pathology, biochemistry, physiology, nutrition, clinical skills, genetics, and selected pathophysiologic mechanisms of these organ systems.
Nancy Wayne (NWayne@mednet.ucla.edu)
Janet Pregler (JaPregler@mednet.ucla.edu)

Block 4: HB&D 404, Musculoskeletal Medicine

Shelley Metten (smetten@mednet.ucla.edu)
Quynh Pham (Quynh.Pham@med.va.gov)

Block 5: HB&D 405 Clinical Neurosciences I
Chris DeGiorgio (cmd@mednet.ucla.edu)
Carolyn Houser (houser@mednet.ucla.edu)
Year 2


Block 6: HB&D 406 Foundations of Medicine II

Basic pharmacology; microbes, host defense and immunity; immune disorders; clinical trials and epidemiology; infectious diseases, including classification of pathogens and therapeutics; disorders of blood.
Larry Feldman, Year 2 (Lfeldman@mednet.ucla.edu)
Matt Leibowitz, Year 2 (Mleibowitz@mednet.ucla.edu)

Block 7: HB&D 407 Gastrointestinal, Endocrine, & Reproductive Medicine II

Endocrinology; reproductive health and disease; breast; GI diseases; gender-specific diseases; skin manifestations of systemic disease; common infectious diseases and therapeutics; common cancers; prevention, including nutrition.
Greg Brent (gbrent@ucla.edu)
Jonathan Hiatt, Year 2 (jhiatt@mednet.ucla.edu)

Block 8: HB&D 408 Clinical Neurosciences II
Margaret Stuber (mstuber@mednet.ucla.edu)
Michael Sofroniew (Sofroniew@mednet.ucla.edu)

Block 9 : HB&D 409 Cardiovascular, Renal, & Respiratory Medicine II

Pathology and pathophysiology of these systems (continued); including hypertension, developmental disorders; therapeutics - pharmaceuticals and other treatments; clinical trials and epidemiology; common cancers; common infectious agents and therapeutics; prevention.
Joshua Goldhaber, Year 2 (Jgoldhaber@mednet.ucla.edu)
Michael Sopher, Year 2 (Msopher@mednet.ucla.edu)

Integrated Exams



Thread Chairs and Content Consultants
  • Clinical Skills/Doctoring - Susan Stangl, MD, Family Medicine
  • Anatomy/Embryology/Histopathology - Shaleen Metten, PhD, Pathology
  • Clinical Reasoning/Informatics - Carl Stevens, MD, Medicine/Emergency
  • Pharmacology - William Melega, PhD, Molecular & Medical Pharmacology
  • Cultural Competency - Paula Henderson, MD, Family Medicine
  • Gender-Based Health - Janet Pregler, MD, Medicine/GIM
  • Geriatrics - Bruce Ferrell, MD, Medicine/Genetics



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