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| Degree: |
Ph.D., University of Chicago - Chicago, Illinois
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| Laboratory Address: |
Laboratory
635 Charles E Young Drive South
NRB 304
Los Angeles, CA 90095
UNITED STATES
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| Office Address: |
Office
635 Charles E Young Drive South
NRB 303
Los Angeles, CA 90095
UNITED STATES
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Work Phone Number:
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310-206-3404
Office
310-267-2105
Laboratory
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Research Interest:
Pattern formation during central nervous system development
My laboratory is addressing the interactions that occur between members of the Hox gene family during embryonic development. Hox genes encode transcription factors that are expressed in broad anteroposterior domains in developing vertebrate embryos. Inactivation of different members of the Hox gene family suggests that these genes are active in embryonic patterning. We have defined the anatomical phenotypes for mice carrying mutations in several individual Hox genes and are currently breeding and analyzing mice carrying multiple mutations. Our studies have demonstrated that motor neuron position and projection is specifically affected by Hox gene mutations both individually and in combination. We are also examining downstream targets of Hox gene activity using microarray screening. We have identified a set of genes that are differentially expressed in the nervous system following mutation of a single Hox gene. Rt-PCR studies have demonstrated that some of these genes show additional changes in expression in double mutant animals, suggesting that several Hox genes may regulate the same downstream target genes. We are currently defining the promoter elements that may be responsible for these gene interactions.
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Choe, A., Phun, H. Q., Tieu, D. D., Hy, Y. H., and Carpenter, E. M. Expression patterns of Hox10 paralogous genes during lumbar spinal cord development.
Gene Expression Patterns.
2006; 7:
730-737.
Hedlund, E., Karsten, S. L., Kudo, L., Geschwind, D. H., and Carpenter, E. M. Identification of a Hoxd10-regulated transcriptional network and combinatorial interactions with Hoxa10 during spinal cord development.
Journal of Neuroscience Research.
2004; 75:
307-319.
Anderson, TR Hedlund, E Carpenter, EM Differential Pax6 promoter activity and transcript expression during forebrain development..
Mechanisms of Development. .
2002; 114(1-2):
171-5.
Wahba, GM Hostikka, SL Carpenter, EM The paralogous Hox genes Hoxa10 and Hoxd10 interact to pattern the mouse hindlimb peripheral nervous system and skeleton..
Developmental Biology. .
2001; 231(1):
87-102.
de la Cruz, CC Der-Avakian, A Spyropoulos, DD Tieu, DD Carpenter, EM Targeted disruption of Hoxd9 and Hoxd10 alters locomotor behavior, vertebral identity, and peripheral nervous system development..
Developmental Biology. .
1999; 216(2):
595-610.
Carpenter, EM Goddard, JM Davis, AP Nguyen, TP Capecchi, MR Targeted disruption of Hoxd-10 affects mouse hindlimb development..
Development (Cambridge, England) .
1997; 124(22):
4505-14.
Carpenter, EM Goddard, JM Chisaka, O Manley, NR Capecchi, MR Loss of Hox-A1 (Hox-1.6) function results in the reorganization of the murine hindbrain..
Development (Cambridge, England) .
1993; 118(4):
1063-75.
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