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Stephen Smale, Ph.D.

Affiliations

Professor and Vice Chair, Microbiology, Immunology & Molecular Genetics

Co-Director, Medical Scientist Training Program

Director, JCCC Gene Regulation Program Area

Education:
Degree:	Ph.D.,

Contact Information:

Work Email Address:	smale@mednet.ucla.edu

Work Address:	Office 6730 MRL 675 Charles E. Young Drive South Los Angeles, CA 90095 UNITED STATES
Work Address:	Laboratory 6525, 6535 MRL 675 Charles E. Young Drive South Los Angeles, CA 90095 UNITED STATES
Work Address:	6-730 MRL CAMPUS - 166222 CA UNITED STATES

Direct Contact Information:

Work Phone Number:	(310) 206-4777

Additional Information:

Stephen T. Smale is a molecular immunologist and biochemist who joined the Department of Microbiology and Immunology at the UCLA School of Medicine in 1990 as an Assistant Professor and as an Investigator with the Howard Hughes Medical Institute. In 1999, he was promoted to full Professor in the newly formed Department of Microbiology, Immunology, and Molecular Genetics, which spans the UCLA College and David Geffen School of Medicine. Dr. Smale graduated Magna Cum Laude from Cornell University, with Honors and Distinction in Chemistry. He received his Ph.D. in Biochemistry from the University of California, Berkeley under the mentorship of Dr. Robert Tjian. He then was a Helen Hay Whitney Foundation postdoctoral fellow with Dr. David Baltimore at the Whitehead Institute, MIT. Dr. Smale is currently Vice Chair of the Department of Microbiology, Immunology, and Molecular Genetics, Co-Director of the UCLA-Caltech Medical Scientist Training Program (MD-PhD Program), and Director of the Gene Regulation Program Area in the UCLA Jonsson Comprehensive Cancer Center. The research in Dr. Smale's laboratory focuses on gene regulation during the development of the immune system and during inflammatory and innate immune responses.

Publications:

Ramirez-Carrozzi VR, Braas D, Bhatt DM, Cheng CS, Hong C, Doty KR, Black JC, Hoffmann A, Carey M, and Smale ST A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodeling. Cell. 2009; 138(1): 114-128.

Carey M, Peterson CL, and Smale ST Transcriptional regulation in eukaryotes: Concepts, strategies, and techniques, Second edition. 2009; Cold Spring Harbor Laboratory Press: .

Reynaud D, Demarco IA, Reddy KL, Schjerven H, Bertolino E, Chen Z, Smale ST, Winandy S, and Singh H Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangement by Ikaros. Nature Immunol. 2008; 9(8): 927-936.

Sridharan R and Smale ST Predominant interaction of both Ikaros and Helios with the NuRD complex in immature thymocytes. J Biol Chem. 2007; 282(41): 30227-30238.

Xu J, Pope SD, Jazirehi AR, Attema JL, Papathanasiou P, Watts JA, Zaret KS, Weissman IL, and Smale ST Pioneer factor interactions and unmethylated CpG dinucleotides mark silent tissue-specific enhancers in embryonic stem cells. Proc Natl Acad Sci. 2007; 104(30): 12377-12382.

Attema JL, Papathanasiou P, Forsberg EC, Xu J, Smale ST, and Weissman IL Epigenetic characterization of hematopoietic stem cell differentiation using miniChIP and bisulfite sequencing analysis. Proc Natl Acad Sci. 2007; 104(30): 12371-12376.

Thompson EC, Cobb BS, Sabbattini P, Meixlsperger S, Parelho V, Liberg D, Taylor B, Dillon N, Georgopoulos K, Jumaa H, Smale ST, Fisher AG, and Merkenschlager M Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits. Immunity. 2007; 26(3): 335-344.

Zhou L, Nazarian AA, Xu J, Tantin D, Corcoran LM, and Smale ST An inducible enhancer required for Il12b promoter activity in an insulated chromatin environment. Mol Cell Biol. 2007; 27(7): 2698-2712.

Ramirez-Carrozzi VR, Nazarian AA, Li CC, Gore SL, Sridharan R, Imbalzano AN, and Smale ST Selective and antagonistic functions of SWI/SNF and Mi-2b nucleosome remodeling complexes during an inflammatory response. Genes & Dev.. 2006; 20: 282-296.

Li CC, Ramirez-Carrozzi VR and Smale ST Pursuing global gene regulation "logic" via RNA interference and chromatin immunoprecipitation. Nature Immunol.. 2006; 7: 692-697.

Cobb BS, Hertweck A, Smith J, O'Connor E, Graf D, Cook T, Smale ST, Sakaguchi S, Livesey FJ, Fisher AG, and Merkenschlager M A role for Dicer in immune regulation. J Exp Med. 2006; 203(11): 2519-2527.

Smale ST and Dorshkind K Hematopoiesis flies high with Ikaros. Nature Immunol.. 2006; 7: 367-369.

Cobb BS, Smale ST Ikaros-family proteins: In search of molecular functions during lympocyte development. . Curr Topics Micro Immunol 2005; (290): 29-47.

Dovat S, Montecino-Rodriguez E, Schuman V, Teitell MA, Dorshkind K, and Smale ST Transgenic expression of Helios in B lineage cells alters B cell properties and promotes lymphomagenesis. J. Immunol.. 2005; 175: 3508-3515.

Sanjabi S, Williams KJ, Saccani S, Zhou L, Hoffmann A, Ghosh G, Gerondakis S, Natoli G, Smale ST A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation.. Genes & Dev.. 2005; 19(18): 2138-51.

Cobb BS, Nesterova TB, Thompson E, Hertweck A, O'Connor E, Godwin J, Wilson CB, Brockdorff N, Fisher AG, Smale ST, Merkenschlager M T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer.. J. Exp. Med.. 2005; 201(9): 1367-73.

Su RC, Sridharan R, Smale ST Assembly of silent chromatin during thymocyte development. Semin. Immunol.. 2005; 17(2): 129-40.

Su RC, Brown KE, Saaber S, Fisher AG, Merkenschlager M, Smale ST Dynamic assembly of silent chromatin during thymocyte maturation.. Nature Genet.. 2004; 36(5): 502-6.

Zhou L, Nazarian AA, Smale ST Interleukin-10 inhibits interleukin-12 p40 gene transcription by targeting a late event in the activation pathway.. Mol. Cell. Biol.. 2004; 24(6): 2385-96.

Cupit PM, Hansen JD, McCarty AS, White G, Chioda M, Spada F, Smale ST, Cunningham C Ikaros family members from the agnathan Myxine glutinosa and the urochordate Oikopleura dioica: emergence of an essential transcription factor for adaptive immunity.. J. Immunol.. 2003; 171(11): 6006-13.

Liberg D, Smale ST, Merkenschlager M Upstream of Ikaros.. Trends Immunol.. 2003; 24(11): 567-70.

Smale ST A Th2 cytokine LCR. Adding a new piece to the regulatory puzzle.. Immunity. . 2003; 19(1): 1-2.

Bradley MN, Zhou L, Smale ST C/EBPbeta regulation in lipopolysaccharide-stimulated macrophages.. Mol. Cell. Biol.. 2003; 23(14): 4841-58.

Smale ST The establishment and maintenance of lymphocyte identity through gene silencing.. Nature Immunol.. 2003; 4(7): 607-15.

Papathanasiou P, Perkins AC, Cobb BS, Ferrini R, Sridharan R, Hoyne GF, Nelms KA, Smale ST, Goodnow CC Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor.. Immunity. . 2003; 19(1): 131-44.

Ronni T, Agarwal V, Haykinson M, Haberland ME, Cheng G, Smale ST Common interaction surfaces of the toll-like receptor 4 cytoplasmic domain stimulate multiple nuclear targets.. Mol. Cell. Biol.. 2003; 23(7): 2543-55.

McCarty AS, Kleiger G, Eisenberg D, Smale ST Selective dimerization of a C2H2 zinc finger subfamily.. Mol. Cell. 2003; 11(2): 459-70.

Smale ST, Kadonaga JT The RNA polymerase II core promoter. Annu Rev Biochem. 2003; 72: 449-79.

Smale ST and Fisher AG Chromatin structure and gene regulation in the immune system.. Annu. Rev. Immunol.. 2002; 20: 427-462.

Dovat S, Ronni T, Russell D, Ferrini R, Cobb BS, Smale ST A common mechanism for mitotic inactivation of C2H2 zinc finger DNA-binding domains.. Genes & Dev.. 2002; 16(23): 2985-90.

Smale ST Core promoters: active contributors to combinatorial gene regulation.. Genes & Dev.. 2001; 15(19): 2503-8.

Trinh LA, Ferrini R, Cobb BS, Weinmann AS, Hahm K, Ernst P, Garraway IP, Merkenschlager M, Smale ST Down-regulation of TDT transcription in CD4(+)CD8(+) thymocytes by Ikaros proteins in direct competition with an Ets activator.. Genes & Dev.. 2001; 15(14): 1817-32.

Weinmann AS, Mitchell DM, Sanjabi S, Bradley MN, Hoffmann A, Liou HC, Smale ST Nucleosome remodeling at the IL-12 p40 promoter is a TLR-dependent, Rel-independent event.. Nat. Immunol.. 2001; 2(1): 51-7.

Sanjabi S, Hoffmann A, Liou HC, Baltimore D, Smale ST Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages.. Proc. Natl. Acad. Sci.. 2000; 97(23): 12705-10.

Cobb BS, Morales-Alcelay S, Kleiger G, Brown KE, Fisher AG, Smale ST Targeting of Ikaros to pericentromeric heterochromatin by direct DNA binding.. Genes & Dev.. 2000; 14(17): 2146-60.

Brightbill HD, Plevy SE, Modlin RL, and Smale ST A prominent role for Sp1 during LPS-mediated induction of the IL-10 promoter in macrophages.. J. Immunology 2000; 164: 1940-1951.

Carey M and Smale ST Transcriptional regulation in eukaryotes: Concepts, strategies, and techniques.. 2000; Cold Spring Harbor Laboratory Press: .

Ernst P, Hahm K, Cobb BS, Brown KE, Trinh LA, McCarty AS, Merkenschlager M, Klug CA, Fisher AG, Smale ST Mechanisms of transcriptional regulation in lymphocyte progenitors: insight from an analysis of the terminal transferase promoter.. Cold Spr. Harb. Symp. Quant. Biol.. 1999; 64: 87-97.

Hahm K, Cobb BS, McCarty AS, Brown KE, Klug CA, Lee R, Akashi K, Weissman IL, Fisher AG, and Smale ST Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin.. Genes & Dev.. 1998; 12: 782-796.

Smale ST, Jain A, Kaufmann J, Emami KH, Lo K, Garraway IP The initiator element: a paradigm for core promoter heterogeneity within metazoan protein-coding genes.. Cold Spr. Harb. Symp. Quant. Biol.. 1998; 63: 21-31.

Weinmann AS, Plevy SE, Smale ST Rapid and selective remodeling of a positioned nucleosome during the induction of IL-12 p40 transcription.. Immunity. . 1999; 11(6): 665-75.

Brightbill HD, Libraty DH, Krutzik SR, Yang RB, Belisle JT, Bleharski JR, Maitland M, Norgard MV, Plevy SE, Smale ST, Brennan PJ, Bloom BR, Godowski PJ, Modlin RL Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.. Science. . 1999; 285(5428): 732-6.

Brown KE, Guest SS, Smale ST, Hahm K, Merkenschlager M, Fisher AG Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin.. Cell. . 1997; 91(6): 845-54.

Emami KH, Jain A, Smale ST Mechanism of synergy between TATA and initiator: synergistic binding of TFIID following a putative TFIIA-induced isomerization.. Genes & Dev.. 1997; 11(22): 3007-19.

Plevy SE, Gemberling JH, Hsu S, Dorner AJ, Smale ST Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteins.. Mol. Cell. Biol. . 1997; 17(8): 4572-88.

Ernst P, Hahm K, Trinh L, Davis JN, Roussel MF, Turck CW, Smale ST A potential role for Elf-1 in terminal transferase gene regulation.. Mol. Cell. Biol.. 1996; 16(11): 6121-31.

Garraway IP, Semple K, Smale ST Transcription of the lymphocyte-specific terminal deoxynucleotidyltransferase gene requires a specific core promoter structure.. Proc. Natl. Acad. Sci.. 1996; 93(9): 4336-41.

Kaufmann J, Verrijzer CP, Shao J, Smale ST CIF, an essential cofactor for TFIID-dependent initiator function.. Genes & Dev. . 1996; 10(7): 873-86.

Emami, KH Navarre, WW Smale, ST Core promoter specificities of the Sp1 and VP16 transcriptional activation domains.. Mol. Cell. Biol.. 1995; 15(11): 5906-16.

Ernst P, Smale ST Combinatorial regulation of transcription II: The immunoglobulin mu heavy chain gene.. Immunity. . 1995; 2(5): 427-38.

Ernst P, Smale ST Combinatorial regulation of transcription. I: General aspects of transcriptional control.. Immunity. . 1995; 2(4): 311-9.


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