Ruan,R., Ren, S., Li, J., Li, G., Kim, R., Gao, J., Wu, H., Wang Y. Inducible and Cardiac Specific PTEN Inactivation Protects Ischemia/Reperfusion Injury. Journal of Molecular and Cellular Cardiology 2009; 46(2): 193-200.

Mulholland, D.J., Xin, L., Morim, A., Lawson, D., Witte, O., and Wu, H. LSC Stem/Progenitors Are Tumor Initiating Cells in the Pten Null Prostate Cancer Model.. Cancer Research 2009; In Press: .

Haga, K., Tomioka, A., Liao, C., Kimura, T., Matsumoto, H., Ohno, I., Hermann, K., Logg, C., Tanaka, M., Hirao, Y., Wu, H., Kruse, C., Roy-Burman, P., and Kasahara N. PTEN knockout prostate cancer as a model for experimental immunotherapy.. The Journal of Urology 2009; 181: 354-362.

Degtyarev, M., De Mazière, A., Orr, C., Lin, J., Tien, J., Prior, W., Lee, B., van Dijk, S., Gray, D., Wu, H., Davis, D., Stern, H., Murray, L., Hoeflich, K., Klumperman, J., Friedman, L. and Lin, K. Akt Inhibition Promotes Autophagy And Sensitizes PTEN-Null Tumors To Late-Stage Autophagy Inhibition.. Journal of Cell Biology 2008; 186: 101-106.

Mulholland, D.J., Jiao, J. and Wu, H. Hormone refractory prostate cancer: lesions leaned from the PTEN prostate cancer model. Adv Exp Med Biol 2008; 617: 87-95.

Iwanaga, K., Yang, Y., Raso, M., Ma, L., Hanna, A., Thilaganathan N., Moghaddam, S., Evans, C., Li, H., Cai, W., Sato, M., Minna, H., Wu, H., Creighton, C., Demayo, F., Wistuba, I. and Kurie, J. Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer.. Cancer Research 2008; 68: 1119-1127.

Vivanco, I., Rohle, D., Versele, M., Palaskas, N., Evans, M., Hsueh, T., Brennan, C., Mulholland, D., Rajasekaran, S., Wolle, D., Rajasekaran, R., Dikic, I., Wu, H., Perera, T. and Mellinghoff, I.K. Regulation of Epidermal Growth Factor Receptor Signaling by the PTEN Tumor Suppressor. 2008; Submitted: .

Shen, W. H., Balajee, A.S., Wang, J., Wu, H., Eng, C., Pandolfi, PP, and Yin, Y. Essential Role for Nuclear PTEN in Maintaining Chromosomal Integrity.. Cell 2007; (128): 157-170.

Vivanco, I., Palaskas, N., Tran, C., Finn, S.P., Getz, G., Kennedy, N.G., Jiao, J., Rose, J., Xie, W., Loda, M., Golub, T., Mellinghoff, I., Davis, R., Wu, H. and Sawyers, C.L Identification of the JNK Signaling Pathway as a Functional Target of the Tumor Suppressor PTEN.. Cancer Cell 2007; (11): 555-569.

He, X., Zhang, J., Grindley, J.C., Tian, Q., Sato, T., Tao, W.A., Dirisina, R., Porter-Westpfahl, K.S., Hembree, M., Johnson, T., Wiedemann, L., Barrett, T., Hood, L., Wu, H. and Li, L. Inactivation of PTEN leads to enhanced activation of intestinal stem cells and biasing on lineage fate determination.. Nature Genetics 2007; (39): 189-198.

Jiao, J., Wang, S., Qiao, R., Vivanco, I., Watson, P., Sawyers, C. and Wu, H. Murine Cell Lines Derived from Pten Null Prostate Cancer Demonstrate the Critical Role of PTEN in Hormone Refractory Prostate Cancer Development. Cancer Research 2007; (67): 6083-6091.

Guo, W. Lasky, J. L., 3rd Wu, H. Cancer stem cells. Pediatr Res. 2006; 59(4 Pt 2): 59R-64R.

Stiles, B., Kurlawalla-Martinez, C., Guo, W., Tian, J. Wang, Y., and Wu, H. Deletion of Pten in insulin producing pancreatic -cells leads to increased -cell mass and rescues STZ-induced diabetes. Molecular Cell Biology 2006; (26): 2772-2781.

Xu, X. Kobayashi, S. Qiao, W. Li, C. Xiao, C. Radaeva, S. Stiles, B. Wang, R. H. Ohara, N. Yoshino, T. LeRoith, D. Torbenson, M. S. Gores, G. J. Wu, H. Gao, B. Deng, C. X. Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice. J Clin Invest. 2006; 116(7): 1843-52.

Lei, Q. Jiao, J. Xin, L. Chang, C. J. Wang, S. Gao, J. Gleave, M. E. Witte, O. N. Liu, X. Wu, H. NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss. Cancer Cell. 2006; 9(5): 367-78.

Wu, H. Khodavirdi, A Roy-Burman, P. Capturing signal anomalies of human prostate cancer into mouse models. Prostate cancer: basic mechanisms and therapeutic approaches 2005; in press.

Liu B, Yang R, Wong KA, Getman C, Stein N, Cheng G, Wu H, and Shuai K PIAS1 Participates in the Negative Regulation of NF-kB Signaling. Mol. Cell Biol. 2005; 25: 1113-23.
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Liu B, Mink S, Wong KA, Stein N, Getman C, Dempsey PW, Wu H, Shuai K PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity. Nat Immunol. 2004; 5(9): 891-8.

Wong KA, Kim R, Christofk H, Gao J, Lawson G, Wu H Protein inhibitor of activated STAT Y (PIASy) and a splice variant lacking exon 6 enhance sumoylation but are not essential for embryogenesis and adult life. Mol Cell Biol. 2004; 24(12): 5577-86.

Freeman DJ, Li AG, Wei G, Li HH, Kertesz N, Lesche R, Whale AD, Martinez-Diaz H, Rozengurt N, Cardiff RD, Liu X, Wu H PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms. Cancer Cell. 2003; 3(2): 117-30.

Anzelon AN, Wu H, Rickert RC Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function. Nat Immunol. 2003; 4(3): 287-94.

Li G, Robinson GW, Lesche R, Martinez-Diaz H, Jiang Z, Rozengurt N, Wagner KU, Wu DC, Lane TF, Liu X, Hennighausen L, Wu H Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland. Development. 2002; 129(17): 4159-70.

Lesche R, Groszer M, Gao J, Wang Y, Messing A, Liu X, and Wu H Cre/loxp-Mediated Inactivation of The Murine Pten Tumor Suppressor Gene.. Genesis. 2002; 32: 148-149.
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Jegalian A and Wu H Differential Regulation of SOCS Gene Expression and Distinct Roles of SOCS family Members in Erythropoietin Receptor Signal Transduction.. J. Cyto.Research . 2002; 22: 3842-3851.
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Jegalian, A., Acurio, A., Dranoff, G., Wu, H. Erythropoietin receptor haploinsufficiency and in vivo interplay with granulocyte-macrophage colony-stimulating factor and interleukine 3.. Blood . 2002; 99: 2603-2605.
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Wong K, Tsai P, Jegalian A, Kertesz N, Lee R and Wu H Erythropoietin.. In Encyclopedia of Hormones and Related Cell Regulators; 2002; .

Stiles B, Gilman V, Khanzenzon N, Lesche R, Li A, Qiao R, Liu X, Wu H Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis. Mol Cell Biol. 2002; 22(11): 3842-51.

Wu H, Klingmuller U, Acurio A, Hsiao JG and Lodish HF Functional Interaction of Erythropoietin and Stem Cell Factor Receptors is Essential for Erythroid Colony Formation.. Proc. Natl. Acad. Sci. USA. . 1997; 94: 1806-1810.
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Klingmuller K, Wu H, Hsiao J, Duckworth B, Toker A, Cantley LC and Lodish HF Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors.. Proc. Natl. Acad. Sci. USA . 1997; 94: 3016-3021.
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Watowich SS, Wu H, Socolovsky M, Klingmuller U, Constantinescu SN, Lodish HF Cytokine receptor signal transduction and the control of hematopoietic cell development. Annu Rev Cell Dev Biol. 1996; 12: 91-128.

Krane SM, Byrne M, Henrie P, Lemaitre V, Jeffrey JJ, Witter J, Liu X, Wu H, Jaenisch R and Eeckhout Y Different collagenase gene products have different roles in remodeling of type I collagen-containing extracellular matrices.. J. Biol. Chem. . 1996; 271: 28509-28515.
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Wu H and Lodish H The erythropoietin receptor: dimerization and intracellular signal transduction. Journal of Experimental hematology 1996; 4: 229-235.

Iruela ML, Vernon RB, Wu H, Jeanisch R and Sage H Type I collagen is required for the association of SPARC with the extracellular matrix in Mov-13 mice: implications for fibroblast function.. Developmental Dynamics . 1996; 207: 171-183.

Wu H, Liu X, Jaenisch R and Lodish H Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor.. Cell. 1995; 83: 59-67.

Lodish HF, Hilton DJ, Klingmuller U, Watowich SS, Wu H The erythropoietin receptor: biogenesis, dimerization, and intracellular signal transduction. Cold Spring Harb Symp Quant Biol. 1995; 60: 93-104.

Liu X, Enfors P, Wu H and Jaenisch R nsory neuron deficit, but show no motor neuron loss.Sensory but not motor neuron deficits in mice lacking NT4 and BDNF. Nature. 1995; 375: 238-241.
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Dzamba, B. J. Wu, H. Jaenisch, R. Peters, D. M. Fibronectin binding site in type I collagen regulates fibronectin fibril formation. J Cell Biol. 1993; 121(5): 1165-72.

Hasty K, Wu H, Byrne M, Goldring M, Jaenisch R, Krane S and Mainardi C Susceptibility of type I collagen containing mutated alpha1(I) chains to cleavage by human neutrophil collagenase.. Matrix. 1993; 13: 181-186.

Wu, H. Fassler, R. Schnieke, A. Barker, D. Lee, K. H. Chapman, V. Francke, U. Jaenisch, R. An X-linked human collagen transgene escapes X inactivation in a subset of cells. Development. 1992; 116(3): 687-95.

Wu, H. Byrne, M. H. Stacey, A. Goldring, M. B. Birkhead, J. R. Jaenisch, R. Krane, S. M. Generation of collagenase-resistant collagen by site-directed mutagenesis of murine pro alpha 1(I) collagen gene. Proc Natl Acad Sci U S A. 1990; 87(15): 5888-92.

Mosessian Sherly, Avliyakulov Nuraly K, Mulholland David J, Boontheung Pinmanee, Loo Joseph A, Wu Hong Analysis of PTEN complex assembly and identification of heterogeneous nuclear ribonucleoprotein C as a component of the PTEN-associated complex.. The Journal of biological chemistry. 2009; 284(44): 30159-66.

Gregorian Michael B, Nakashima Michael B, Dry Michael B, Nghiemphu Michael B, Smith Michael B, Ao Michael B, Dang Michael B, Lawson Michael B, Mellinghoff Michael B, Mischel Michael B, Phelps Michael B, Parada Michael B, Liu Michael B, Sofroniew Michael B, Eilber Michael B, Wu Michael B PTEN dosage is essential for neurofibroma development and malignant transformation.. Proceedings of the National Academy of Sciences of the United States of America. 2009; 48(47): .

Hill Reginald, Wu Hong PTEN, stem cells, and cancer stem cells.. The Journal of biological chemistry. 2009; 284(18): 11755-9.

Gregorian Caroline, Nakashima Jonathan, Le Belle Janel, Ohab John, Kim Rachel, Liu Annie, Smith Kate Barzan, Groszer Matthias, Garcia A Denise, Sofroniew Michael V, Carmichael S Thomas, Kornblum Harley I, Liu Xin, Wu Hong Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesis.. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009; 29(6): 1874-86.

Guertin David A, Stevens Deanna M, Saitoh Maki, Kinkel Stephanie, Crosby Katherine, Sheen Joon-Ho, Mullholland David J, Magnuson Mark A, Wu Hong, Sabatini David M mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice.. Cancer cell. 2009; 15(2): 148-59.

Conway Anne E, Lindgren Anne, Galic Zoran, Pyle April D, Wu Hong, Zack Jerome A, Pelligrini Matteo, Teitell Michael A, Clark Amander T A self-renewal program controls the expansion of genetically unstable cancer stem cells in pluripotent stem cell-derived tumors.. Stem cells (Dayton, Ohio). 2009; 27(1): 18-28.

Couto Suzana S, Cao Mei, Duarte Paulo C, Banach-Petrosky Whitney, Wang Shunyou, Romanienko Peter, Wu Hong, Cardiff Robert D, Abate-Shen Cory, Cunha Gerald R Simultaneous haploinsufficiency of Pten and Trp53 tumor suppressor genes accelerates tumorigenesis in a mouse model of prostate cancer.. Differentiation; research in biological diversity. 2009; 77(1): 103-11.

Valamehr Bahram, Jonas Steven J, Polleux Julien, Qiao Rong, Guo Shuling, Gschweng Eric H, Stiles Bangyan, Kam Korey, Luo Tzy-Jiun M, Witte Owen N, Liu Xin, Dunn Bruce, Wu Hong Hydrophobic surfaces for enhanced differentiation of embryonic stem cell-derived embryoid bodies.. Proceedings of the National Academy of Sciences of the United States of America. 2008; 105(38): 14459-64.

Majumder Pradip K, Grisanzio Chiara, O'Connell Fionnuala, Barry Marc, Brito Joseph M, Xu Qing, Guney Isil, Berger Raanan, Herman Paula, Bikoff Rachel, Fedele Giuseppe, Baek Won-Ki, Wang Shunyou, Ellwood-Yen Katharine, Wu Hong, Sawyers Charles L, Signoretti Sabina, Hahn William C, Loda Massimo, Sellers William R A prostatic intraepithelial neoplasia-dependent p27 Kip1 checkpoint induces senescence and inhibits cell proliferation and cancer progression.. Cancer cell. 2008; 14(2): 146-55.

Burton Jeremy B, Johnson Mai, Sato Makoto, Koh Sok Boon S, Mulholland David J, Stout David, Chatziioannou Arion F, Phelps Michael E, Wu Hong, Wu Lily Adenovirus-mediated gene expression imaging to directly detect sentinel lymph node metastasis of prostate cancer.. Nature medicine. 2008; 14(8): 882-8.

Yao Denggao, Alexander Claire L, Quinn Jean A, Chan Weng-Chyn, Wu Hong, Greenhalgh David A Fos cooperation with PTEN loss elicits keratoacanthoma not carcinoma, owing to p53/p21 WAF-induced differentiation triggered by GSK3beta inactivation and reduced AKT activity.. Journal of cell science. 2008; 121(Pt 10): 1758-69.

Guo Wei, Lasky Joseph L, Chang Chun-Ju, Mosessian Sherly, Lewis Xiaoman, Xiao Yun, Yeh Jennifer E, Chen James Y, Iruela-Arispe M Luisa, Varella-Garcia Marileila, Wu Hong Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation.. Nature. 2008; 453(7194): 529-33.

Chang Chun-Ju, Mulholland David J, Valamehr Bahram, Mosessian Sherly, Sellers William R, Wu Hong PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression.. Molecular and cellular biology. 2008; 28(10): 3281-9.

Kwon Chang-Hyuk, Zhao Dawen, Chen Jian, Alcantara Sheila, Li Yanjiao, Burns Dennis K, Mason Ralph P, Lee Eva Y-H P, Wu Hong, Parada Luis F Pten haploinsufficiency accelerates formation of high-grade astrocytomas.. Cancer research. 2008; 68(9): 3286-94.

Memarzadeh, S., Xin, L., Mulholland, D., Mansukhani,A., Wu, H., Teitell,M., and Witte, O. Enhanced Paracrine FGF10 Expression Promotes Formation of Multifocal Prostate Adenocarcinoma and an Increase in Epithelial Androgen Receptor.. Cancer Cell. 2007; 12(6): 572-585.

Tahk S., Liu, B., Chenishof, V., Wong, K., Wu, H. and Shuai, K. Control of specificity and magnitude of NF-kB and STAT1-mediated gene activation through PIASy and PIAS1 co-operation.. Proceddings of the National Academy of Sciences, USA. 2007; 104(28): 11643-11648.

Berquin, I.M., Min, Y., Wu, R., Wu, J., Perry, D., Cline, J.M., Thomas, M.J., Thornburg, T., Kulik. G., Smith, A., Edward, I.J., D’Agostino, R., Zhang, H., Wu, H., Kang, J.X., Chen, Y.Q. Modulation of Prostate Cancer Genetic Risk by Omega-3 and Omega-6 Fatty Acids.. Journal of Clinical Investigation. 2007; 117(7): 1866-1875.

Horvath, S. Zhang, B. Carlson, M. Lu, K. V. Zhu, S. Felciano, R. M. Laurance, M. F. Zhao, W. Qi, S. Chen, Z. Lee, Y. Scheck, A. C. Liau, L. M. Wu, H. Geschwind, D. H. Febbo, P. G. Kornblum, H. I. Cloughesy, T. F. Nelson, S. F. Mischel, P. S. Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target. Proc Natl Acad Sci U S A. 2006; 103(46): 17402-7.

Huang, W. Chang, H. Y. Fei, T. Wu, H. Chen, Y. G. GSK3beta mediates suppression of cyclin D2 expression by tumor suppressor PTEN. Oncogene. 2006; .

Freeman, D. Lesche, R. Kertesz, N. Wang, S. Li, G. Gao, J. Groszer, M. Martinez-Diaz, H. Rozengurt, N. Thomas, G. Liu, X. Wu, H. Genetic background controls tumor development in PTEN-deficient mice. Cancer Res. 2006; 66(13): 6492-6.

Zhang, J. Grindley, J. C. Yin, T. Jayasinghe, S. He, X. C. Ross, J. T. Haug, J. S. Rupp, D. Porter-Westpfahl, K. S. Wiedemann, L. M. Wu, H. Li, L. PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention. Nature. 2006; 441(7092): 518-22.

Yilmaz, O. H. Valdez, R. Theisen, B. K. Guo, W. Ferguson, D. O. Wu, H. Morrison, S. J. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature. 2006; 441(7092): 475-82.

Li, G. Hu, Y. Huo, Y. Liu, M. Freeman, D. Gao, J. Liu, X. Wu, D. Wu, H. PTEN deletion leads to up-regulation of a secreted growth factor pleiotrophin. J Biol Chem. 2006; .

Yoo, L. I. Liu, D. W. Le Vu, S. Bronson, R. T. Wu, H. Yuan, J. Pten deficiency activates distinct downstream signaling pathways in a tissue-specific manner. Cancer Res. 2006; 66(4): 1929-39.

Yao, D. Alexander, C. L. Quinn, J. A. Porter, M. J. Wu, H. Greenhalgh, D. A. PTEN loss promotes rasHa-mediated papillomatogenesis via dual up-regulation of AKT activity and cell cycle deregulation but malignant conversion proceeds via PTEN-associated pathways. Cancer Res. 2006; 66(3): 1302-12.

Wang S, Garcia AJ, Wu M, Lawson DA, Witte ON, Wu H Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation. Proc Natl Acad Sci U S A. 2006; 103(5): 1480-5.

Tsai PT, Ohab JJ, Kertesz N, Groszer M, Matter C, Gao J, Liu X, Wu H, Carmichael ST A critical role of erythropoietin receptor in neurogenesis and post-stroke recovery. J Neurosci. 2006; 26(4): 1269-74.

Mulholland, D. J. Dedhar, S. Wu, H. Nelson, C. C. PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer. Oncogene. 2006; 25(3): 329-37.

Khodavirdi, A. C. Song, Z. Yang, S. Zhong, C. Wang, S. Wu, H. Pritchard, C. Nelson, P. S. Roy-Burman, P. Increased expression of osteopontin contributes to the progression of prostate cancer. Cancer Res. 2006; 66(2): 883-8.

Groszer M, Erickson R, Scripture-Adams DD, Dougherty JD, Le Belle J, Zack JA, Geschwind DH, Liu X, Kornblum HI, Wu H PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry. Proc Natl Acad Sci U S A. 2006; 103(1): 111-6.

Berquin, I. M. Min, Y. Wu, R. Wu, H. Chen, Y. Q. Expression signature of the mouse prostate. J Biol Chem. 2005; 280(43): 36442-51.

Stanger BZ, Stiles B, Lauwers GY, Bardeesy N, Mendoza M, Wang Y, Greenwood A, Cheng KH, McLaughlin M, Brown D, Depinho RA, Wu H, Melton DA, Dor Y Pten constrains centroacinar cell expansion and malignant transformation in the pancreas.. Cancer cell. . 2005; 8(3): 185-95.

Nakano I, Paucar AA, Bajpai R, Dougherty JD, Zewail A, Kelly TK, Kim KJ, Ou J, Groszer M, Imura T, Freije WA, Nelson SF, Sofroniew MV, Wu H, Liu X, Terskikh AV, Geschwind DH, Kornblum HI Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation. J Cell Biol. 2005; 170(3): 413-27.

Yue Q, Groszer M, Gil JS, Berk AJ, Messing A, Wu H, Liu X PTEN deletion in Bergmann glia leads to premature differentiation and affects laminar organization.. Development (Cambridge, England) . 2005; 132(14): 3281-91.
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Lasky JL, Wu H Notch signaling, brain development, and human disease.. Pediatric research. . 2005; 57(5 Pt 2): 104R-109R.
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Shi, Y. Sharma, A. Wu, H. Lichtenstein, A. Gera, J. Cyclin D1 and c-myc internal ribosome entry site (IRES)-dependent translation is regulated by AKT activity and enhanced by rapamycin through a p38 MAPK- and ERK-dependent pathway. J Biol Chem. 2005; 280(12): 10964-73.

Sanchez, T. Thangada, S. Wu, M. T. Kontos, C. D. Wu, D. Wu, H. Hla, T. PTEN as an effector in the signaling of antimigratory G protein-coupled receptor. Proc Natl Acad Sci U S A. 2005; 102(12): 4312-7.

Kurlawalla-Martinez C, Stiles B, Wang Y, Devaskar SU, Kahn BB, Wu H Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue.. Molecular and cellular biology. . 2005; 25(6): 2498-510.
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Lim, M. A. Yang, L. Zheng, Y. Wu, H. Dong, L. Q. Liu, F. Roles of PDK-1 and PKN in regulating cell migration and cortical actin formation of PTEN-knockout cells. Oncogene. 2004; 23(58): 9348-58.

Kertesz N, Wu J, Chen TH, Sucov HM, Wu H The role of erythropoietin in regulating angiogenesis. Dev Biol. 2004; 276(1): 101-10.

Stiles B, Groszer M, Wang S, Jiao J, Wu H PTENless means more. Dev Biol. 2004; 273(2): 175-84.

Chang CJ, Freeman DJ, Wu H PTEN regulates Mdm2 expression through the P1 promoter.. The Journal of biological chemistry. . 2004; 279(28): 29841-8.

Johnson JD, Han Z, Otani K, Ye H, Zhang Y, Wu H, Horikawa Y, Misler S, Bell GI, Polonsky KS RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets. J Biol Chem. 2004; 279(23): 24794-802.

Roy-Burman P, Wu H, Powell WC, Hagenkord J, Cohen MB Genetically defined mouse models that mimic natural aspects of human prostate cancer development.. Endocrine-related cancer. . 2004; 11(2): 225-54.

Sundaresan G, Paulmurugan R, Berger F, Stiles B, Nagayama Y, Wu H, Gambhir SS MicroPET imaging of Cre-loxP-mediated conditional activation of a herpes simplex virus type 1 thymidine kinase reporter gene.. Gene therapy. . 2004; 11(7): 609-18.

Stiles B, Wang Y, Stahl A, Bassilian S, Lee WP, Kim YJ, Sherwin R, Devaskar S, Lesche R, Magnuson MA, Wu H Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]. Proc Natl Acad Sci U S A. 2004; 101(7): 2082-7.

Tsao H, Goel V, Wu H, Yang G, Haluska FG Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma.. The Journal of investigative dermatology. . 2004; 122(2): 337-41.

Tsai, P. T. Lee, R. A. Wu, H. BMP4 acts upstream of FGF in modulating thymic stroma and regulating thymopoiesis. Blood. 2003; 102(12): 3947-53.

Wang S, Gao J, Lei Q, Rozengurt N, Pritchard C, Jiao J, Thomas GV, Li G, Roy-Burman P, Nelson PS, Liu X, Wu H Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer.. Cancer cell. . 2003; 4(3): 209-21.

Anzelon AN, Wu H, Rickert RC Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function.. Nature immunology. . 2003; 4(3): 287-94.
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Osawa M, Yamaguchi T, Nakamura Y, Kaneko S, Onodera M, Sawada K, Jegalian A, Wu H, Nakauchi H, Iwama A Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis.. Blood. . 2002; 100(8): 2769-77.
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Kertesz, N. Samson, J. Debacker, C. Wu, H. Labastie, M. C. Cloning and characterization of human and mouse SNRK sucrose non-fermenting protein (SNF-1)-related kinases. Gene. 2002; 294(1-2): 13-24.

Jegalian, AG Wu, H Regulation of Socs gene expression by the proto-oncoprotein GFI-1B: two routes for STAT5 target gene induction by erythropoietin.. The Journal of biological chemistry. . 2002; 277(3): 2345-52.
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Hisakawa H, Sugiyama D, Nishijima I, Xu MJ, Wu H, Nakao K, Watanabe S, Katsuki M, Asano S, Arai K, Nakahata T, Tsuji K Human granulocyte-macrophage colony-stimulating factor (hGM-CSF) stimulates primitive and definitive erythropoiesis in mouse embryos expressing hGM-CSF receptors but not erythropoietin receptors. Blood. 2001; 98(13): 3618-25.

Groszer, M. Erickson, R. Scripture-Adams, D. D. Lesche, R. Trumpp, A. Zack, J. A. Kornblum, H. I. Liu, X. Wu, H. Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Science. 2001; 294(5549): 2186-9.

Lee R, Kertesz N, Joseph SB, Jegalian A, Wu H Erythropoietin (Epo) and EpoR expression and 2 waves of erythropoiesis. Blood. 2001; 98(5): 1408-15.

Neshat MS, Mellinghoff IK, Tran C, Stiles B, Thomas G, Petersen R, Frost P, Gibbons JJ, Wu H, Sawyers CL Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc Natl Acad Sci U S A. 2001; 98(18): 10314-9.

Dubey P, Wu H, Reiter RE, Witte ON Alternative pathways to prostate carcinoma activate prostate stem cell antigen expression. Cancer Res. 2001; 61(8): 3256-61.

Makita, T. Hernandez-Hoyos, G. Chen, T. H. Wu, H. Rothenberg, E. V. Sucov, H. M. A developmental transition in definitive erythropoiesis: erythropoietin expression is sequentially regulated by retinoic acid receptors and HNF4. Genes Dev. 2001; 15(7): 889-901.

Mamillapalli R, Gavrilova N, Mihaylova VT, Tsvetkov LM, Wu H, Zhang H, Sun H PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2). Curr Biol. 2001; 11(4): 263-7.

Satterthwaite, A. B. Willis, F. Kanchanastit, P. Fruman, D. Cantley, L. C. Helgason, C. D. Humphries, R. K. Lowell, C. A. Simon, M. Leitges, M. Tarakhovsky, A. Tedder, T. F. Lesche, R. Wu, H. Witte, O. N. A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase. Proc Natl Acad Sci U S A. 2000; 97(12): 6687-92.

Liliental J, Moon SY, Lesche R, Mamillapalli R, Li D, Zheng Y, Sun H, Wu H Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases. Curr Biol. 2000; 10(7): 401-4.

Ghaffari, S. Wu, H. Gerlach, M. Han, Y. Lodish, H. F. Daley, G. Q. BCR-ABL and v-SRC tyrosine kinase oncoproteins support normal erythroid development in erythropoietin receptor-deficient progenitor cells. Proc Natl Acad Sci U S A. 1999; 96(23): 13186-90.

Wu H, Lee SH, Gao J, Liu X, Iruela-Arispe ML Inactivation of erythropoietin leads to defects in cardiac morphogenesis.. Development (Cambridge, England) . 1999; 126(16): 3597-605.
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Sun H, Lesche R, Li DM, Liliental J, Zhang H, Gao J, Gavrilova N, Mueller B, Liu X, Wu H PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Proc Natl Acad Sci U S A. 1999; 96(11): 6199-204.

Neubauer H, Cumano A, Muller M, Wu H, Huffstadt U, Pfeffer K Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell. 1998; 93(3): 397-409.

Constantinescu, S. N. Wu, H. Liu, X. Beyer, W. Fallon, A. Lodish, H. F. The anemic Friend virus gp55 envelope protein induces erythroid differentiation in fetal liver colony-forming units-erythroid. Blood. 1998; 91(4): 1163-72.

Liu X, Wu H, Loring J, Hormuzdi S, Disteche CM, Bornstein P, Jaenisch R Trisomy eight in ES cells is a common potential problem in gene targeting and interferes with germ line transmission.. Developmental dynamics : an official publication of the American Association of Anatomists. . 1997; 209(1): 85-91.
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Klingmuller U, Wu H, Hsiao JG, Toker A, Duckworth BC, Cantley LC, Lodish HF Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors. Proc Natl Acad Sci U S A. 1997; 94(7): 3016-21.

Wu, H. Klingmuller, U. Acurio, A. Hsiao, J. G. Lodish, H. F. Functional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation. Proc Natl Acad Sci U S A. 1997; 94(5): 1806-10.

Liu X, Wu H, Byrne M, Krane S, Jaenisch R Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development. Proc Natl Acad Sci U S A. 1997; 94(5): 1852-6.

Wu, H. Klingmuller, U. Besmer, P. Lodish, H. F. Interaction of the erythropoietin and stem-cell-factor receptors. Nature. 1995; 377(6546): 242-6.

Liu X, Wu H, Byrne M, Jeffrey J, Krane S, Jaenisch R A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling.. The Journal of cell biology. . 1995; 130(1): 227-37.
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Wu, H. Liu, X. Jaenisch, R. Double replacement: strategy for efficient introduction of subtle mutations into the murine Col1a-1 gene by homologous recombination in embryonic stem cells. Proc Natl Acad Sci U S A. 1994; 91(7): 2819-23.

Barker DD, Wu H, Hartung S, Breindl M, Jaenisch R Retrovirus-induced insertional mutagenesis: mechanism of collagen mutation in Mov13 mice.. Molecular and cellular biology. . 1991; 11(10): 5154-63.
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Wu H, Bateman JF, Schnieke A, Sharpe A, Barker D, Mascara T, Eyre D, Bruns R, Krimpenfort P, Berns A Human-mouse interspecies collagen I heterotrimer is functional during embryonic development of Mov13 mutant mouse embryos.. Molecular and cellular biology. . 1990; 10(4): 1452-60.
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Silverman, D. H. Wu, H. Karnovsky, M. L. Muramyl peptides and serotonin interact at specific binding sites on macrophages and enhance superoxide release. Biochem Biophys Res Commun. 1985; 131(3): 1160-7.