The ability to generate sequence and marker data in almost any region of the human genome facilitates the mapping of genes that contribute to diseases and other traits which have a genetic factor in their origins. These sequence and marker data also permit the identification of the specific alleles contributing to disease. When the data is coupled with the appropriate statistical analyses, it greatly increases our power to investigate conditions with a genetic component. Further, with the rapid increase in the quantity and availability of sequence data from multiple species, identification of genes, functional domains of genes, and even novel metabolic pathways can be accomplished. The Bioinformatics Core provides advice for study design, computer-based investigation, and statistical analysis. The Core has two complementary divisions. The facility in Young Hall is focused on protein analysis. The Gonda Center Core is focused on genetic analysis. Here investigators are provided with the necessary computers and programs to accomplish their gene mapping and identification goals. The two divisions have a close interaction, and share expertise, computer programs and facilities. In addition, the Bioinformatics Core plays an important role in the interdepartmental Bioinformatics program at UCLA.