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Irvin Chen, Ph.D.
Affiliations
Professor, Microbiology, Immunology & Molecular Genetics
Member, ACCESS Program: Dept. of Microbiology, Immunology, & Molecular Genetics, JCCC Hematopoietic Malignancies Program Area
Education:
Degree: Ph.D.,
Contact Information:
Work Email Address: syuchen@mednet.ucla.edu
Laboratory Address: Laboratory
BSRB, Rm 161

UNITED STATES
Mailing Address: Mailing Address
BSRB, Rm 173
615 Charles E. Young Dr. South
Los Angeles, CA 90095
UNITED STATES
Work Address: Office
BSRB, Rm 190
CAMPUS - 796322
CA
UNITED STATES
Direct Contact Information:
Work Phone Number: (310) 825-4793 Office
(310) 825-6873 Laboratory
Additional Information:

Dr. Irvin S. Y. Chen, Director of the UCLA AIDS Institute, is Professor of Microbiology, Immunology, Molecular Genetics and Professor of Medicine at the David Geffen School of Medicine at UCLA, and is an internationally recognized retrovirologist and molecular biologist. Dr. Chen’s focus is on human retroviruses that are implicated in cancer and AIDS. This form of virus reproduces by creating DNA from RNA and adding its genetic code to the chromosomes of the cells it has infected. Along with his exploration of the disease-causing process of the AIDS virus—HIV (human immunodeficiency virus), Dr. Chen also was instrumental in identifying HTLV II, a human T-cell leukemia virus. Dr. Chen was the co-inventor of a diagnostic test for this virus currently used in blood banks throughout the world.

Publications:
De Ugarte DA, Morizono K, Elbarbary A, Alfonso Z, Zuk PA, Zhu M, Dragoo JL, Ashjian P, Thomas B, Benhaim P, Chen I, Fraser J, Hedrick MH Comparison of multi-lineage cells from human adipose tissue and bone marrow.. Cells, tissues, organs. . 2003; 174(3): 101-9.
Amado SP, Chen ISY Biomedicine: Lentiviral Vectors-The Promise of Gene Therapy Within Reach?. Science 1999; 285, 5428: 674-676.
Poon B, Ferbas KG, Stewart SA, Chen ISY HIV-1 Vpr in virions induces cell cycle arrest and is insensitive to antiretroviral agents.. Science 1998; 281: 266-269.
Cao Y, Krogstad P, Korber BT, Koup RA, Muldoon M, Macken C, Song LJ, Jin Z, Zhao JQ, Clapp S, Chen ISY, Ho DD, Ammann AJ, and the Ariel Project Investigators Maternal HIV-1 viral load and vertical transmission of infection.. Nature Medicine 1997; 3, 5: 549-552.
Camerini D, Planelles V, Chen ISY D26 antigen and HIV fusion?. Science 1994; 264: 1160-1161.
Aldrovandi GM, Feuer G, Gao L, Kristeva M, Chen ISY, Zack JA An animal model for virus pathogenesis.. Nature 1993; 363: 732-736.
Lee H, Swanson P, Shorty VS, Zack JA, Rosenblatt JD, Chen ISY High rate of HTLV-11 infection in seropositive IV drug abusers from New Orleans.. Science 1989; 244: 471-475.
Zack JA, Cann AJ, Lugo JP, Chen ISY AIDS virus production from infected peripheral blood T cells following HTLV-1-induced mitogenic stimulation.. Science 1988; 240: 1026-1029.
Rosenblatt JD, Cann AJ, Slamon DJ, Smalberg IS, Shah NP, Fujii J, Wachsman W, Chen ISY HTLV-11 trans-activation is regulated by two overlapping nonstructural genes.. Science 1988; 240: 916-919.
Morizono K, Xie Y, Ringpis GE, Johnson M, Nassanian H, Lee B, Wu L, Chen IS Lentiviral vector retargeting to P-glycoprotein on metastatic melanoma through intravenous injection.. Nature medicine. . 2005; 11(3): 346-52.
Sugiyama O, An DS, Kung SP, Feeley BT, Gamradt S, Liu NQ, Chen IS, Lieberman JR Lentivirus-mediated gene transfer induces long-term transgene expression of BMP-2 in vitro and new bone formation in vivo.. Molecular therapy : the journal of the American Society of Gene Therapy. . 2005; 11(3): 390-8.
Donahue RE, Chen IS Transgene-specific tolerance versus immune response.. Blood. . 2004; 104(5): 1578-9; author reply 1579.
Kung SK, An DS, Bonifacino A, Metzger ME, Ringpis GE, Mao SH, Chen IS, Donahue RE Induction of transgene-specific immunological tolerance in myeloablated nonhuman primates using lentivirally transduced CD34+ progenitor cells.. Molecular therapy : the journal of the American Society of Gene Therapy. . 2003; 8(6): 981-91.
An DS, Xie Y, Mao SH, Morizono K, Kung SK, Chen IS Efficient lentiviral vectors for short hairpin RNA delivery into human cells.. Human gene therapy. . 2003; 14(12): 1207-12.
Stewart SA, Dykxhoorn DM, Palliser D, Mizuno H, Yu EY, An DS, Sabatini DM, Chen IS, Hahn WC, Sharp PA, Weinberg RA, Novina CD Lentivirus-delivered stable gene silencing by RNAi in primary cells.. RNA (New York, N.Y.) . 2003; 9(4): 493-501.
Yuan H, Xie YM, Chen IS Depletion of Wee-1 kinase is necessary for both human immunodeficiency virus type 1 Vpr- and gamma irradiation-induced apoptosis.. Journal of virology. . 2003; 77(3): 2063-70.
Qin XF, An DS, Chen IS, Baltimore D Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5.. Proceedings of the National Academy of Sciences of the United States of America. . 2003; 100(1): 183-8.
Morizono K, Bristol G, Xie YM, Kung SK, Chen IS Antibody-directed targeting of retroviral vectors via cell surface antigens.. Journal of virology. . 2001; 75(17): 8016-20.
Morizono K, Bristol G, Xie YM, Kung SK, Chen IS Antibody-directed targeting of retroviral vectors via cell surface antigens.. Journal of virology. . 2001; 75(17): 8016-20.
Stewart SA, Poon B, Jowett JB, Xie Y, Chen IS Lentiviral delivery of HIV-1 Vpr protein induces apoptosis in transformed cells.. Proceedings of the National Academy of Sciences of the United States of America. . 1999; 96(21): 12039-43.
Frenkel LM, Mullins JI, Learn GH, Manns-Arcuino L, Herring BL, Kalish ML, Steketee RW, Thea DM, Nichols JE, Liu SL, Harmache A, He X, Muthui D, Madan A, Hood L, Haase AT, Zupancic M, Staskus K, Wolinsky S, Krogstad P, Zhao J, Chen I, Koup R, Ho D, Korber B, Apple RJ, Coombs RW, Pahwa S, Roberts NJ Genetic evaluation of suspected cases of transient HIV-1 infection of infants.. Science. . 1998; 280(5366): 1073-7.
Withers-Ward ES, Amado RG, Koka PS, Jamieson BD, Kaplan AH, Chen IS, Zack JA Transient renewal of thymopoiesis in HIV-infected human thymic implants following antiviral therapy.. Nature medicine. . 1997; 3(10): 1102-9.
Stewart SA, Poon B, Jowett JB, Chen IS Human immunodeficiency virus type 1 Vpr induces apoptosis following cell cycle arrest.. Journal of virology. . 1997; 71(7): 5579-92.
An DS, Koyanagi Y, Zhao JQ, Akkina R, Bristol G, Yamamoto N, Zack JA, Chen IS High-efficiency transduction of human lymphoid progenitor cells and expression in differentiated T cells.. Journal of virology. . 1997; 71(2): 1397-404.
O'Brien WA, Koyanagi Y, Namazie A, Zhao JQ, Diagne A, Idler K, Zack JA, Chen IS HIV-1 tropism for mononuclear phagocytes can be determined by regions of gp120 outside the CD4-binding domain.. Nature. . 1990; 348(6296): 69-73.
Zack JA, Arrigo SJ, Weitsman SR, Go AS, Haislip A, Chen IS HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure.. Cell. . 1990; 61(2): 213-22.
Pang S, Koyanagi Y, Miles S, Wiley C, Vinters HV, Chen IS High levels of unintegrated HIV-1 DNA in brain tissue of AIDS dementia patients.. Nature. . 1990; 343(6253): 85-9.
Koyanagi Y, O'Brien WA, Zhao JQ, Golde DW, Gasson JC, Chen IS Cytokines alter production of HIV-1 from primary mononuclear phagocytes.. Science. . 1988; 241(4873): 1673-5.


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