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Eric Sobel, Ph.D.

Affiliations

Adjunct Professor, Human Genetics

Education:
Degree:	Ph.D., UCLA, 1996

Contact Information:

Work Email Address:	esobel@ucla.edu

Direct Contact Information:

Technical Research Interest:

Statistcal Genetic Algorithms for Complex Pedigrees

When collecting family-based data for genetic studies, it is not uncommon to find large extended pedigrees with many individuals exhibiting the disease under study, even when only looking for nuclear families. These large pedigrees are tremendous sources of genetic information, however extracting all the information is one of the most computationally intense tasks in biology. One of my research interests is developing efficient methods using Markov chain Monte Carlo techniques to mine the data stored in large family histories. The software I have developed is widely used to help locate the genes that contribute to diseases ranging from rare hereditary traits such as Ataxia-Telangiectasia to complex common traits such as migraine and diabetes.

Additional Information:

Eric Sobel received his PhD from the UCLA Department of Biomathematics in 1996. However, having grown up in much colder climates, he does not take Califormia's beautiful and varied environments for granted. So, after a few years in Oxford and Paris, he and his fellow bioinformatician wife Jeanette Papp were glad to return and join the faculty at the newly-minted Department of Human Genetics.

Publications:

Lange, K Sinsheimer, JS Sobel, E Association testing with Mendel.. Genetic epidemiology. . 2005; 29(1): 36-50.

Song, KK Weeks, DE Sobel, E Feingold, E Efficient simulation of P values for linkage analysis.. Genetic epidemiology. . 2004; 26(2): 88-96.

Lilja, HE Suviolahti, E Soro-Paavonen, A Hiekkalinna, T Day, A Lange, K Sobel, E Taskinen, MR Peltonen, L Perola, M Pajukanta, P Locus for quantitative HDL-cholesterol on chromosome 10q in Finnish families with dyslipidemia.. Journal of lipid research. . 2004; 45(10): 1876-84.

Sobel, E Papp, JC Lange, K Detection and integration of genotyping errors in statistical genetics.. American journal of human genetics. . 2002; 70(2): 496-508.

Wessman M, Kallela M, Kaunisto MA, Marttila P, Sobel E, Hartiala J, Oswell G, Leal SM, Papp JC, Hamalainen E, Broas P, Joslyn G, Hovatta I, Hiekkalinna T, Kaprio J, Ott J, Cantor R, Zwart J-A, Ilmavirta M, Havanka H, Farkkila M, Peltonen L, Palotie A A susceptibility locus for migraine with aura on chromosome 4q24. American Journal of Human Genetics 2002; 70: 652-662.

Saarela J, Schoenberg Fejzo M, Chen D, Finnila S, Parkkonen M, Kuokkanen S, Sobel E, Tienari PJ, Sumelahti M-L, Wikstrom J, Elovaara I, Koivisto K, Pirttila T, Reunanen M, Palotie A, Peltonen L Fine mapping of a multiple sclerosis locus to 2.5 Mb on chromosome 17q22-q24. Human Molecular Genetics 2002; 11: 2257-2267.

Sobel, E Sengul, H Weeks, DE Multipoint estimation of identity-by-descent probabilities at arbitrary positions among marker loci on general pedigrees.. Human heredity. . 2001; 52(3): 121-31.

Magre J, Delpine M, Khallouf E, Gedde-Dahl T, Van Maldergem L, Sobel E, Papp J, Meier M, Mgarban A, BSCL Working Group, Lathrop M, Capeau J Mutations in the human homologue of GNG3LG cause Berardinelli-Seip congenital lipodystrophy linked to chromosome 11q13. Nature Genetics 2001; 28: 365-370.

Ekelund J, Hovatta I, Parker A, Paunio T, Varilo T, Martin R, Suhonen J, Ellonen P, Chan G, Sinsheimer JS, Sobel E, Juvonen H, Arajarvi R, Partonen T, Suvisaari J, Lonnqvist J, Meyer J, Peltonen L Chromosome 1 loci in Finnish schizophrenia families.. Human Molecular Genetics 2001; 10: 1611-1617.

Keavney, B McKenzie, CA Connell, JM Julier, C Ratcliffe, PJ Sobel, E Lathrop, M Farrall, M Measured haplotype analysis of the angiotensin-I converting enzyme gene.. Human molecular genetics. . 1998; 7(11): 1745-51.

Sobel E, Weeks DE Haplotype analysis. Encyclopedia of Biostatistics 1998; 3: 1804-1812.

Davis S, Sobel E, Marinov M, Weeks DE Analysis of bipolar disorder using affected relatives (Genetic Analysis Workshop 10: Detection of genes for complex traits). Genetic Epidemiology 1997; 14: 605-610.

Sobel, E Lange, K Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker-sharing statistics.. American journal of human genetics. . 1996; 58(6): 1323-37.

Sobel E, Lange K, O'Connell JR, Weeks DE Haplotyping algorithms. Genetic mapping and DNA sequencing (IMA Volumes in Mathematics and its Applications) 1996; 81: 89-110.

Lange, E Borresen, AL Chen, X Chessa, L Chiplunkar, S Concannon, P Dandekar, S Gerken, S Lange, K Liang, T Localization of an ataxia-telangiectasia gene to an approximately 500-kb interval on chromosome 11q23.1: linkage analysis of 176 families by an international consortium.. American journal of human genetics. . 1995; 57(1): 112-9.

Weeks, DE Sobel, E O'Connell, JR Lange, K Computer programs for multilocus haplotyping of general pedigrees.. American journal of human genetics. . 1995; 56(6): 1506-7.

Sobel, E Lange, K Metropolis sampling in pedigree analysis.. Statistical methods in medical research. . 1993; 2(3): 263-82.

Lange E, Gatti RA, Sobel E, Concannon P, Lange K How many ataxia-telangiectasia genes. Ataxia-Telangiectasia (NATO ASI Series) 1993; H77: 37-54.

Sobel E, Lange E, Jaspers NGJ, Chessa L, Sanal O, Shiloh Y, Taylor AMR, Weemaes CMA, Lange K, Gatti RA Ataxia-telangiectasia: linkage evidence for genetic heterogeneity. American Journal of Human Genetics 1992; 50: 1343-1348.

Sanal, O Lange, E Telatar, M Sobel, E Salazar-Novak, J Ersoy, F Morrison, A Concannon, P Tolun, A Gatti, RA Ataxia-telangiectasia: linkage analysis of chromosome 11q22-23 markers in Turkish families.. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. . 1992; 6(10): 2848-52.

Lange, K Sobel, E A random walk method for computing genetic location scores.. American journal of human genetics. . 1991; 49(6): 1320-34.

Foroud T, Wei S, Ziv Y, Sobel E, Lange E, Chao A, Goradia T, Huo Y, Tolun A, Chessa L, Charmley P, Sanal O, Salman N, Julier C, Concannon P, McConville C, Taylor AMR, Shiloh Y, Lange K, Gatti RA Localization of an ataxia-telangiectasia locus to a 3 cM interval on chromosome 11q23: linkage analyses of 111 families by an international consortium. American Journal of Human Genetics 1991; 49: 1263-1279.

Gatti RA, Lange E, Sobel E, Lange K Localization of the ataxia-telangiectasia gene(s) to a 3 cM interval on chromosome 11q23 by linkage analysis. Cytogenetics and Cell Genetics 1991; 58: 1959-1960.

Barstow T, Cooper D, Sobel E, Landaw E, Epstein S Influence of increased metabolic rate on [13C] bicarbonate washout kinetics. American Journal of Physiology 1990; 259: R163-R171.

Sobel E, Martinez H A multiple sequence alignment program. Nucleic Acids Research 1986; 14: 363-374.


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