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Alexander van der Bliek, Ph.D.
Affiliations
Professor, Biological Chemistry
Member, ACCESS Program: Dept. of Biological Chemistry, JCCC Cancer Cell Biology Program Area, JCCC Basic Research
Education:
Degree: Ph.D.,
Contact Information:
Email Address: avan@mednet.ucla.edu
Office Address: 351C BSRB
CAMPUS - 173717
CA
UNITED STATES
Work Address: Office
Biological Sciences Research Building
Los Angeles, CA 90095
UNITED STATES
Work Address: Laboratory
Biological Sciences Research Building
Los Angeles, CA 90095
UNITED STATES
Direct Contact Information:
Work Phone Number: 310-206-1755 Laboratory
310-825-9779 Office
Publications:
Kanazawa, T., Zappaterra M.D., Hasegawa, A., Wright A.P., Newman-Smith, E.D., Buttle, K., McDonald K.L., Mannella, C.A. & van der Bliek A.M. The C. elegans Opa1 Homologue EAT-3 is Essential for Resistance to Free Radicals. PLoS Genetics 2008; 4: e-pub.
Gandre-Babbe, S. & van der Bliek, A. M. The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells. Mol Biol Cell 2008; In press.
Hasegawa, A. & van der Bliek, A.M. Functions of C. elegans and mammalian Mdm38/LetM1 homologues. Hum. Molec. Genet. 2007; 16: 2061-2071.
Gandre, S. & van der Bliek, A.M. Mitochondrial division in C. elegans. Methods in Molecular Biology 2007; 372: 485-501.
Griparic, L. Kanzawa , T. & van der Bliek, A.M. Regulation of the mitochondrial dynamin like protein Opa1 by proteolytic cleavage. J. Cell Biol 2007; 178: 757-764.
van der Bliek, A. M. A sixth sense for Rab5. Nat. Cell Biol. 2005; 7: 548-550.
Griparic, L. & van der Bliek, A.M. Assay and properties of mammalian Opa1/Mgm1 in mitochrondrial morphology. Methods in Enzymology 2005; 404: 620-631.
Griparic L, Head B & van der Bliek AM Mitochondrial division and fusion.. Topics in Curr. Genet. 2004; 8: 227-249.
Rube DA, van der Bliek AM Mitochondrial morphology is dynamic and varied.. Molecular and cellular biochemistry. . 2004; 256-257(1-2): 331-9.
Smirnova E, D -L Shurland & AM van der Bliek Mapping Dynamin Interdomain Interactions with Yeast Two-Hybrid and GST-Pulldown Experiments.. Methods in Enzymology 2001; 329: 468-477.
Marcotte EM, I Xenarios, AM van der Bliek & D Eisenberg Discovering organellar proteins from their phylogenetic profiles.. Proc. Natl. Acad. Sci. USA 2000; 97: 12115-12120.
van der Bliek AM Is Dynamin a Regular Motor or a Master Regulator?. Trends Cell Biol. 1999; 9: 253-254.
Labrousse AM, Shurland D-L & van der Bliek AM Contribution of the GTPase domain to the intracellular localization of dynamin in the nematode C.elegans.. Molec. Biol. Cell 1998; 9: 3227-3239.
Clark S, DL Shurland, EM Meyerowitz, CI Bargmann & AM van der Bliek Dynamin GTPase mutation causes a rapid reversible, temperature-inducible locomotion defect in C. elegans.. Proc. Natl. Acad. Sci. USA 1997; 94: 10438-10443.
Seedorf K, G Kstka, R Lammers, P Bashkin, R Daly, WH Burgess, AM van der Bliek, J Schlessinger & A Ullrich Dynamin binds to the SH3 domains of phospholipase Cg and GRB-2.. J. Biol. Chem. 1994; 269: 16009-16014.
Borst P & AM van der Bliek Amplification of several genes in MDR Chinese hamster cell lines.. Molecular and Cellular Biology of Multidrug Resistance 1991; 107-116.
Lincke CR, AM van der Bliek, GJ Schuurhuis, T van der Velde Koerts, JM Smit, & P Borst The multidrug resistance phenotype of human BRO melanoma cells transfected with a wild-type human mdr1 cDNA.. Cancer Res. 1990; 50: 1779-1785.
van der Bliek AM & P Borst Multidrug resistance.. Adv. Cancer Res. 1989; 52: 165-203.
van der Bliek AM, MB Meyers, JL Biedler, E Hes, & P Borst A 21-kDa protein, overproduced in MDR cells, is homologous to the calcium-binding light chain of calpain.. EMBO J. 1986; 5: 3201-3208.
Bienfait HF, Bino RJ, van der Bliek AM, Duivenvoorden J & Fontaine JM Characterization of ferric reducing activity in roots of Fe-deficient P. vulgaris.. Physiol. Plant. 1983; 59: 196-202.
Tabak HF, Osinga KA, de Vries E, van der Bliek AM, van der Horst GTJ, Groot-Koerkamp MJA & van der Horst G Initiation of transcription of yeast mitochondrial DNA.. Mitochondria 1983 1983; 79-93.
Bienfait HF, van der Bliek AM & Bino RJ Different regulations of ferric reduction and acidification of the medium by roots of Fe-stressed plants in a 'rhizostat'.. J. Plant Nutr. 1982; 5: 447-50.
van der Bliek AM, el Gharably Z, Pieterse AH & Scheepens MM Observations of the phenology of Potamogeton pectinatus L. and other submersed weeds in irrigation systems in Egypt.. Proc. EWRS 6th Symposium on Aquatic Weeds 1982; 37-44.
Griparic L, van der Wel NN, Orozco IJ, Peters PJ, van der Bliek AM Loss of the intermembrane space protein Mgm1/OPA1 induces swelling and localized constrictions along the lengths of mitochondria.. The Journal of biological chemistry. . 2004; 279(18): 18792-8.
Schuske KR, Richmond JE, Matthies DS, Davis WS, Runz S, Rube DA, van der Bliek AM, Jorgensen EM Endophilin is required for synaptic vesicle endocytosis by localizing synaptojanin.. Neuron. . 2003; 40(4): 749-62.
van der Bliek AM, Koehler CM A mitochondrial rhomboid protease.. Developmental cell. . 2003; 4(6): 769-70.
Garrido N, Griparic L, Jokitalo E, Wartiovaara J, van der Bliek AM, Spelbrink JN Composition and dynamics of human mitochondrial nucleoids.. Molecular biology of the cell. . 2003; 14(4): 1583-96.
Smirnova E, Griparic L, Shurland DL, van der Bliek AM Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells.. Molecular biology of the cell. . 2001; 12(8): 2245-56.
Griparic L, van der Bliek AM The many shapes of mitochondrial membranes.. Traffic (Copenhagen, Denmark) . 2001; 2(4): 235-44.
van der Bliek AM A mitochondrial division apparatus takes shape.. The Journal of cell biology. . 2000; 151(2): F1-4.
Labrousse AM, Zappaterra MD, Rube DA, van der Bliek AM C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membrane.. Molecular cell. . 1999; 4(5): 815-26.
Smirnova E, Shurland DL, Newman-Smith ED, Pishvaee B, van der Bliek AM A model for dynamin self-assembly based on binding between three different protein domains.. The Journal of biological chemistry. . 1999; 274(21): 14942-7.
van der Bliek AM Functional diversity in the dynamin family.. Trends in cell biology. . 1999; 9(3): 96-102.
Smirnova E, Shurland DL, Ryazantsev SN, van der Bliek AM A human dynamin-related protein controls the distribution of mitochondria.. The Journal of cell biology. . 1998; 143(2): 351-8.
Newman-Smith ED, Shurland DL, van der Bliek AM Assignment of the dynamin-1 gene (DNM1) to human chromosome 9q34 by fluorescence in situ hybridization and somatic cell hybrid analysis.. Genomics. . 1997; 41(2): 286-9.
Estes PS, Roos J, van der Bliek AM, Kelly RB, Krishnan KS, Ramaswami M Traffic of dynamin within individual Drosophila synaptic boutons relative to compartment-specific markers.. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 1996; 16(17): 5443-56.
Damke H, Baba T, van der Bliek AM, Schmid SL Clathrin-independent pinocytosis is induced in cells overexpressing a temperature-sensitive mutant of dynamin.. The Journal of cell biology. . 1995; 131(1): 69-80.
Ramaswami M, Rao S, van der Bliek AM, Kelly RB, Krishnan KS Genetic studies on dynamin function in Drosophila.. Journal of neurogenetics. . 1993; 9(2): 73-87.
van der Bliek AM, Redelmeier TE, Damke H, Tisdale EJ, Meyerowitz EM, Schmid SL Mutations in human dynamin block an intermediate stage in coated vesicle formation.. The Journal of cell biology. . 1993; 122(3): 553-63.
van der Bliek AM, Meyerowitz EM Dynamin-like protein encoded by the Drosophila shibire gene associated with vesicular traffic.. Nature. . 1991; 351(6325): 411-4.
van der Bliek AM, Kooiman PM, Schneider C, Borst P Sequence of mdr3 cDNA encoding a human P-glycoprotein.. Gene. . 1988; 71(2): 401-11.
Van der Bliek AM, Baas F, Van der Velde-Koerts T, Biedler JL, Meyers MB, Ozols RF, Hamilton TC, Joenje H, Borst P Genes amplified and overexpressed in human multidrug-resistant cell lines.. Cancer research. . 1988; 48(21): 5927-32.
van der Bliek AM, Lincke CR, Borst P Circular DNA of 3T6R50 double minute chromosomes.. Nucleic acids research. . 1988; 16(11): 4841-51.
Van der Bliek AM, Baas F, Ten Houte de Lange T, Kooiman PM, Van der Velde-Koerts T, Borst P The human mdr3 gene encodes a novel P-glycoprotein homologue and gives rise to alternatively spliced mRNAs in liver.. The EMBO journal. . 1987; 6(11): 3325-31.
Borst P, Van der Bliek AM, Van der Velde-Koerts T, Hes E Structure of amplified DNA, analyzed by pulsed field gradient gel electrophoresis.. Journal of cellular biochemistry. . 1987; 34(4): 247-58.
Jongsma AP, Spengler BA, Van der Bliek AM, Borst P, Biedler JL Chromosomal localization of three genes coamplified in the multidrug-resistant CHRC5 Chinese hamster ovary cell line.. Cancer research. . 1987; 47(11): 2875-8.
Deuchars KL, Du RP, Naik M, Evernden-Porelle D, Kartner N, van der Bliek AM, Ling V Expression of hamster P-glycoprotein and multidrug resistance in DNA-mediated transformants of mouse LTA cells.. Molecular and cellular biology. . 1987; 7(2): 718-24.
de Bruijn MH, Van der Bliek AM, Biedler JL, Borst P Differential amplification and disproportionate expression of five genes in three multidrug-resistant Chinese hamster lung cell lines.. Molecular and cellular biology. . 1986; 6(12): 4717-22.
Ragoussis J, van der Bliek AM, Trowsdale J, Ziegler A Mapping of HLA genes using pulsed-field gradient electrophoresis.. FEBS letters. . 1986; 204(1): 1-4.
Schinkel AH, Groot Koerkamp MJ, Van der Horst GT, Touw EP, Osinga KA, Van der Bliek AM, Veeneman GH, Van Boom JH, Tabak HF Characterization of the promoter of the large ribosomal RNA gene in yeast mitochondria and separation of mitochondrial RNA polymerase into two different functional components.. The EMBO journal. . 1986; 5(5): 1041-7.
Van der Bliek AM, Van der Velde-Koerts T, Ling V, Borst P Overexpression and amplification of five genes in a multidrug-resistant Chinese hamster ovary cell line.. Molecular and cellular biology. . 1986; 6(5): 1671-8.
Osinga KA, Van der Bliek AM, Van der Horst G, Groot Koerkamp MJ, Tabak HF, Veeneman GH, Van Boom JH In vitro site-directed mutagenesis with synthetic DNA oligonucleotides yields unexpected deletions and insertions at high frequency.. Nucleic acids research. . 1983; 11(24): 8595-608.


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