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Kenneth L. Lange, Ph.D.
Affiliations
Maxine and Eugene Rosenfeld Professor of Computational Genetics, Human Genetics
Chair, Human Genetics
Professor, Biomathematics, Statistics
Member, ACCESS Program: Dept. of Human Genetics, Bioinformatics IDP
Education:
Degree: Ph.D., Massachusetts Institute of Technology, 1971
Contact Information:
Email Address: klange@ucla.edu; klange@mednet.ucla.edu
Office Address: 5357A
Gonda (Goldschmied) Neuroscience & Genetics Research Center
695 Charles E. Young Drive South
Los Angeles, CA 90095
Direct Contact Information:
Work Phone Number: 310-206-8076 Office
Additional Information:

Kenneth Lange is the Maxine and Eugene Rosenfeld Professor of Computational Genetics and Chair of the Department of Human Genetics. He previously served as chair of the Department of Biomathematics for nine years and has held permanent or visiting appointments at the University of New Hampshire, University of Michigan, University of Helsinki, M.I.T, Harvard, and Stanford. He has authored four advanced textbooks and published nearly 200 scientific papers.

Two themes dominate Dr. Lange's research. One is the development of novel mathematical methods in optimization theory, applied probability, and computational statistics. The other is a devotion to realistic biological modeling. Although there is bound to be a tension between these two poles, the advancement of the biomedical sciences depends on bridging the gap. His contributions to genetic epidemiology, population genetics, membrane physiology, demography, oncology, and medical imaging highlight some of the connections. Many of his landmark papers predate by a decade or more the current flood of biological applications of hidden Markov chains, Markov chain Monte Carlo, and high-dimensional optimization.

Dr. Lange has also made important software contributions to the human genetics community. His program Mendel is the Swiss army knife of statistical genetics packages. He and faculty colleague Eric Sobel are constantly adding new utilities, with a recent emphasis on special handling of the enormous data sets generated by SNP (single nucleotide polymorphism) association studies.

Neil Risch, Michael Boehnke, Daniel Weeks, Eric Sobel, Eric Schadt, and Laura Lazzeroni are among his former graduate students. This list constitutes a Who's Who of statistical genetics. He continues to mentor and inspire bright students who combine mathematical talent with biological curiosity.

Books

Lange K (2004) Optimization. Springer-Verlag, New York
Lange K (2003) Applied Probability. Springer-Verlag, New York
Lange K (2002) Mathematical and Statistical Methods for Genetic Analysis, 2nd ed.
       Springer-Verlag, New York
Lange K (1999) Numerical Analysis for Statisticians. Springer-Verlag, New York



Publications:
Wu TT, Chen YF, Hastie T, Sobel EM, Lange K Genomewide association analysis by lasso penalized logistic regression. Bioinformatics 2009; 25: 714-721.
de Leeuw J, Lange K Sharp quadratic majorization in one dimension. Computational Stat Data Analysis 2009; 53: 2471–2484.
Bauman LE, Sinsheimer JS, Sobel EM, Lange K Mixed effects models for quantitative trait loci mapping with inbred strains. Genetics 2008; 180: 1743-1761.
Ayers KL, Lange K Penalized estimation of haplotype frequencies. Bioinformatics 2008; 24: 1596–1602.
Park CC, Ahn S, Bloom JS, Lin A, Wang RT, Wu TT, Sekar A, Khan AH, Farr CJ, Lusis AJ, Leahy RM, Lange K, Smith DJ Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids. Nature Genetics 2008; 40: 421–429.
Sinsheimer JS, Plaisier CL, Huertas-Vazquez A, Aguilar-Salinas C, Tusie-Luna T, Pajukanta P, Lange K Estimating ethnic admixture from pedigree data. Amer J Hum Genet 2008; 82: 748–755.
Wu TT, Lange K Coordinate descent algorithms for lasso penalized regression. Annals Appl Stat 2008; 2: 224–244.
Suchard MA, Lange K, Sinsheimer JS Efficiency of protein production from mRNA. J Stat Theory Practice 2008; 2: 173–182.
Lange K, Wu T An MM algorithm for multicategory vertex discriminant analysis. J Computational Graphical Stat 2008; 17: 527–544.
Lange K Reflections on The Cauchy-Schwarz Master Class. The Mathematical Scientist 2008; 33: 1–7.
Sabatti C, Lange K Bayesian Gaussian mixture models for high density genotyping arrays. JASA 2008; 103: 89–100.
Ayers KL, Sabatti C, Lange K A dictionary model for haplotyping, genotype calling, and association testing. Genet Epid 2007; 31: 672-683.
Presson AP, Sobel E, Lange K, Papp JC Merging microsatellite data. J Comp Biol 2006; 13: 1131–1147.
Crespi CM, Lange K Estimation for the simple linear Boolean model. Methodology Computing Appl Prob 2006; 8: 559–571.
Chen GK, Slaten E, Ophoff RA, Lange K Accommodating chromosome inversions in linkage analysis. Amer J Hum Genet 2006; 79: 238–251.
Lange K, Sobel E Variance component models for X-linked QTLs. Genet Epid 2006; 30: 380–383.
Ayers KL, Sabatti C, Lange K Reconstructing ancestral haplotypes with a dictionary model. J Comp Biol 2006; 13: 767–785.
Greenawalt DM, Cui X, Wu Y, Lin Y, Wang H-Y, Luo M, Tereshchenko IV, Hu G, Li J-Y, Chu Y, Azaro MA, DeCoste CJ, Chimge N-O, Gao R, Shen L, Shih WJ, Lange K, Li H Strong correlation between meiotic crossovers and haplotype structure on the long arm of chromosome 21. Genome Res 2005; 16: 208–214.
Lange K, Sinsheimer JS, Sobel E Association testing with Mendel. Genet Epid 2005; 29: 36–50.
Bauman L, Almasy L, Blangero J, Duggirala R, Sinsheimer JS, Lange K Fishing for pleiotropic QTLs in a polygenic sea. Ann Hum Genet 2005; 69: 590-611.
Cantor RM, Chen GK, Pajukanta P, Lange K Association testing in a linked region using large pedigrees. Amer J Hum Genet 2005; 76: 538–542.
Sabatti C, Rohlin L, Lange K, Liao JC Vocabulon: a dictionary model approach for reconstruction and localization of transcription factor binding sites. Bioinformatics 2005; 21: 922–931.
Lilja HE, Suviolahti E, Soro-Paavonen A, Hiekkalinna T, Day A, Lange K, Sobel E, Taskinen M-R, Peltonen L, Perola M, Pajukanta P Locus for quantitative HDL-cholesterol on chromosome 10q in Finnish families with dyslipidemia. J Lipid Res 2004; 45: 1876–1884.
Lange K, Sinsheimer JS The pedigree trimming problem. Hum Hered 2004; 58: 108–11.
Dorman K, Sinsheimer JS, Lange K In the garden of branching processes. SIAM Review 2004; 46: 202–229.
Lange EM, Lange K Powerful allele-sharing statistics for non-parametric linkage analysis. Hum Hered 2004; 57: 49–58.
Hunter DR, Lange K A tutorial on MM algorithms. Amer Statistician 2004; 58: 30–37.
Lange K Computational statistics and optimization theory at UCLA. Amer Statistician 2004; 58: 9–11.
Sabatti C, Lange K Genomewide motif identification using a dictionary model. Proceedings IEEE 2002; 90: 1803–1810.
Schadt EE, Sinsheimer JS, Lange K Applications of codon and rate variation models in molecular phylogeny. Mol Biol Evol 2002; 19: 1550–1562.
Schadt EE, Lange K Codon and rate variation models in molecular phylogeny. Mol Biol Evol 2002; 19: 1534-1549.
Berloff N, Perola M, Lange K Spline methods for comparison of physical and genetic maps. J Comp Biol 2002; 9: 465–476.
Liao W-H, Huang S-C, Lange K, Bergsneider M. Edited by Senda M, Kimura Yuichi, Herscovitch P, Kimura Yui Use of MM algorithm for regularization of parametric images in dynamic PET. Brain Imaging Using PET 2002; 107–114.
Liao W-H, Lange K, Huang S-C, Bergsneider M Optimal design in PET data acquisition: a new approach using simulated annealing and component-wise Metropolis updating. Nuclear Science Symposium Conference Record, IEEE 2002; 4: 1979–1983.
Sobel E, Papp J, Lange K Detection and integration of genotyping errors in statistical genetics. Amer J Hum Genet 2002; 496–508.
Ro KM, Cantor RM, Lange K, Ahn SS Palmer hyperhidrosis: evidence of genetic transmission. J Vascular Surgery 2002; 35: 382–386.
Hunter DR, Lange K Computing estimates in the proportional odds model. Ann Inst Stat Math 2002; 54: 155.
Lange K, Redelings B. Edited by Sneyd J Disease gene dynamics in a population isolate. An Introduction to Mathematical Modeling in Physiology, Cell Biology, and Immunology. American Mathematical Society, Providence, RI 2002; 119–138.
Sinsheimer JS, McKenzie CA, Keavney B, Lange K SNPs and snails and puppy dogs’ tails: analysis of SNP data using the gamete competition model. Ann Hum Genet 2001; 65: 483–490.
Perola M, Ohman M, Hiekkalinna T, Leppavuori J, Pajukanta P, Wessman M, Koskenvuo M, Palotie A, Lange K, Kaprio J, Peltonen L Quantitative-trait locus analysis of body mass index and stature, by combined analysis of genome scans of five Finnish study groups. Amer J Hum Genet 2001; 69: 117-123.
Peltonen L, Palotie A, Lange K The use of population isolates for mapping complex traits. Nature Genetics Reviews 2000; (1): 182–190.
Dorman KS, Kaplan AH, Lange K, Sinsheimer JS Mutation takes no vacation. Can structured treatment interruptions increase the risk of drug resistant HIV-1?. JAIDS 2000; 25: 398–402.
Douglas JA, Boehnke M, Lange K A multipoint method for detecting genotyping errors and mutations in sibling-pair linkage data. Amer J Hum Genet 2000; 66: 1287–1297.
Sinsheimer JS, Blangero J, Lange K Gamete competition models. Amer J Hum Genet 2000; 66: 1168-1172.
Guo SW, Lange K Genetic mapping of complex traits: promises, problems, and prospects. Theor Pop Bio 2000; (57): 1–11.
Fan R, Lange K. Edited by Gesztesy F, Holden H, Jost J, Paycha S, Rocker M, Scarlatti S Asymptotic properties of the maximal subinterval of a Poisson process. Stochastic Processes, Physics and Geometry: New Interplays II: A Volume in Honor of Sergio Albeverio. American Mathematical Society, CMS Conference Proceedings Series 2000; (29): 175–187.
Lange EM, Chen H, Brierley K, Livermore H, Wojno KJ, Langefeld CD, Lange K, Cooney KA The polymorphic exon 1 androgen receptor CAG repeat in men with a potential inherited predisposition to prostate cancer. Cancer Epidemiology, Biomarkers, Prevention 2000; (9): 439–442.
Hunter DR, Lange K Quantile regression via an MM algorithm. J Comput Graphical Stat 2000; (9): 60–77.
Lange K, Hunter DR, Yang I Optimization transfer using surrogate objective functions (with discussion). J Comput Graphical Stat 2000; 9: 1-59.


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