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Wayne Grody, M.D., Ph.D.
Affiliations
Member, JCCC Genitourinary Oncology Program Area
Education:
Medical Degree: M.D., Baylor College of Medicine, 1977
Degree: Ph.D.
Certifications:
Medical Board Certification: Molecular Genetic Pathology, American Board of Pathology, 2001
Clinical Biochemical Genetics, American Board of Medical Genetics, 1990
Clinical Genetics, American Board of Medical Genetics, 1990
Anatomic & Clinical Pathology, American Board of Pathology, 1987
Education:
Residency: Medicine/Pathology, UCLA School of Medicine, 1987
Fellowship: Genetics, UCLA School of Medicine, 1986
Contact Information:
Work Email Address: wgrody@mednet.ucla.edu
Laboratory Address: 1P-266, 1P-439 CHS

UNITED STATES
Work Address: Office
CHS 1P-249
CAMPUS - 173216
CA
UNITED STATES
Direct Contact Information:
Additional Information:

Wayne W. Grody, M.D., Ph.D. is a Professor in the Departments of Pathology & Laboratory Medicine, Pediatrics, and Human Genetics at the UCLA School of Medicine. He is the director of the Diagnostic Molecular Pathology Laboratory within the UCLA Medical Center, one of the first such facilities in the country to offer DNA-based tests for diagnosis of a wide variety of genetic, infectious, and neoplastic diseases, as well as bone marrow engraftment, patient specimen identification and paternity testing by DNA fingerprinting. He is also an attending physician in the Department of Pediatrics, specializing in the care of patients with or at risk for genetic disorders. He has been one of the primary developers of quality assurance and ethical guidelines for DNA-based genetic testing for a number of governmental and professional agencies including the FDA, AMA, CAP, ACMG, ASHG, NCCLS, CDC, NIH-DOE Human Genome Project (ELSI program), and PSRGN. He served as a member of the NIH-DOE Task Force on Genetic Testing, and was the working group chair for development of national guidelines for cystic fibrosis and factor V-Leiden mutation screening. Most recently, he was appointed chair of an Advisory Committee on Genomic Medicine for the entire VA healthcare system. He did his undergraduate work at Johns Hopkins University, received his M.D. and Ph.D. at Baylor College of Medicine, and completed residency and fellowship training at UCLA. He is double board-certified by the American Board of Pathology (Anatomic and Clinical Pathology, Molecular Genetic Pathology) and the American Board of Medical Genetics (Clinical Genetics, Molecular Genetics, and Biochemical Genetics).
Publications:
Mumenthaler, S.M., H. Yu, S. Tze, S.D. Cederbaum, A.E. Pegg, D.B. Seligson and W.W. Grody. . Differential expression of arginase II in androgen-dependent versus androgen-independent prostate cancer.. Int. J. Oncol. 2008; 32: 357-365..
Deignan, J.L., S.D. Cederbaum and W.W. Grody . Contrasting features of urea cycle disorders in human patients and knockout mouse models.. Molec. Genet. Metab. 2008; 93: 7-14.
Deignan JL, Marescau B, Livesay JC, Iyer RK, De Deyn PP, Cederbaum SD, Grody WW. Increased plasma and tissue guanidino compounds in a mouse model of hyperargininemia.. Molec.l Genet. Metab. 2008; 93: 172-178.
Deignan, J.L., J. Livesay, L.M. Shantz, A.E. Pegg AE, W. O'brien, R.K. Iyer, S.D. Cederbaum and W.W. Grody. Polyamine homeostasis in arginase knockout mice. . Am. J. Physiol. Cell Physiol. 2007; 293: C1296-1301.
Elshimali, Y., Grody, W.W. Clinical significance of circulating tumor cells in the peripheral blood.. Diagn. Molec. Pathol. 2006; 15: 187-194.
Deignan, J.L., P.K. Yoo, J.C. Livesay, S.I. Goodman, W.E. O���Brien, R.K. Iyer, S.D. Cederbaum and W.W. Grody. Ornithine deficiency in the arginase double knockout mouse. Molec. Genet. Metab. 2006; 89: 87-96.
Ojino, S, R.B. Wilson, B. Gold, P. Hawley and W.W. Grody. Bayesian analysis for cystic fibrosis risks in prenatal and carrier screening.. Genet. Med. 2004; 6: 439-449.
Richards, C.S. and W.W. Grody. Prenatal screening for cystic fibrosis: Past, present and future. . Exp. Rev. Molec. Diagn. 2004; 4: 49-62.
Venegas, P.B., J.M. Novak, O.A. Castro, F.L. Sanchez, I.G. Gutierrez, R.M. Julio, M.F. Jenny, R.M. Gonzalez, J.P. Salas and W.W. Grody. CFTR mutations in Costa Rica. Hum. Biol. 2003; 75: 179-188.
Grody, WW Ethical issues raised by genetic testing with oligonucleotide microarrays.. Molec. Biotechnol 2003; 23: 127-138.
Kim, P.S., R.K. Iyer, K.V. Lu, H. Yu, A. Karemi, R.M. Kern, D. Tai, J. Miller, M. Weiss, S.D. Cederbaum and W.W. Grody. Expression of the liver form of arginase in erythrocytes. . Molec. Genet. Metab. 2002; 76: 100-110.
Grody WW, Griffin JH, Taylor AK, Korf BR, Heit JA American College of Medical Genetics consensus statement on factor V Leiden mutation testing.. Genet. Med. 2001; 3: 139-148.
Grody WW, Cutting GR, Klinger KW, Richards CS, Watson MS, Desnick RJ Laboratory standards and guidelines for population-based cystic fibrosis carrier screening.. Genetics in medicine : official journal of the American College of Medical Genetics. . 2001; 3(2): 149-54.
Telatar M, Grody WW Molecular genetic testing for familial Mediterranean fever.. Molecular genetics and metabolism. . 2000; 71(1-2): 256-60.
Grody WW Cystic fibrosis: Molecular diagnosis, population screening, and public policy.. Arch. Pathol. Lab. Med. 1999; 123: 1041-1046.
Grody, W.W. and R.E. Pyeritz Report card on molecular genetic testing: Room for improvement? . JAMA 1999; 281: 845-847.
Grody, W.W., R.J. Desnick, N.J. Carpenter and W.W. Noll Diversity of cystic fibrosis mutation screening practices. Am. J. Hum. Genet. 1998; 62: 1252-1254.
Grody, WW Molecular pathology, informed consent, and the paraffin block. Diagn. Mol. Pathol. 1995; 4: 155-157.
Goodman BK, Tabor DE, Kern RM, Vockley JG, Wissmann PB, Cederbaum SD, Grody WW Functional analysis of the liver arginase promotor and adjacent 5' flanking sequences from man and Macaca fascicularis.. Som. Cell Molec. Genet. 1994; 20: 313-325.
Jarvis M, Iyer RK, Williams LO, Noll WW, Thomas K, Telatar M, Grody WW A novel method for creating artificial mutant samples for performance evaluation and quality control in clinical molecular genetics.. The Journal of molecular diagnostics : JMD. . 2005; 7(2): 247-51.
Iyer RK, Bando JM, Jenkinson CP, Vockley JG, Kim PS, Kern RM, Cederbaum SD, Grody WW Cloning and characterization of the mouse and rat type II arginase genes.. Molecular genetics and metabolism. . 1998; 63(3): 168-75.
Grody WW, Dunkel-Schetter C, Tatsugawa ZH, Fox MA, Fang CY, Cantor RM, Novak JM, Bass HN, Crandall BF PCR-based screening for cystic fibrosis carrier mutations in an ethnically diverse pregnant population.. American journal of human genetics. . 1997; 60(4): 935-47.
Wissmann PB, Goodman BK, Vockley JG, Kern RM, Cederbaum SD, Grody WW Delivery of cytosolic liver arginase into the mitochondrial matrix space: a possible novel site for gene replacement therapy.. Somatic cell and molecular genetics. . 1996; 22(6): 489-98.


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