| Medical Degree: |
M.D., Yale University School of Medicine, 1991
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| Degree: |
Ph.D., Yale University
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| Medical Board Certification: |
Neurology, American Board of Psychiatry and Neurology, 1996
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| Fellowship: |
Neurogenetics, UCLA School of Medicine, 1997
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| Residency: |
Neurology, UCLA School of Medicine, 1995
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| Internship: |
Internal Medicine, UCLA School of Medicine, 1992
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| Mailing Address: |
Laboratory
695 Charles E Young Dr South
Los Angeles, CA 90095
UNITED STATES
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| Office Address: |
Office
695 Charles E Young Dr South
Los Angeles, CA 90095
UNITED STATES
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Work Phone Number:
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(310) 794-6570
office
(310) 794-7537
laboratory
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Dr. Daniel Geschwind holds the Gordon and Virginia MacDonald Distinguished Chair in Human Genetics and is a professor of Neurology and Psychiatry at the UCLA School of Medicine. He is director of the Neurogenetics Program and the Center for Autism Research and Treatment (CART) and co-director of the Center for Neurobehavioral Genetics.
Dr. Geschwind obtained an A.B. in psychology and chemistry at Dartmouth College and his M.D./Ph.D. at Yale School of Medicine, prior to completing his internship, residency, and postdoctoral fellowship at UCLA. He joined the UCLA faculty in 1997.
Dr. Geschwind's laboratory conducts research in three primary areas of neurogenetics: autism and language; focal neurodegenerative syndromes; and the structural/molecular basis of human cognitive specializations. Utilizing a multi-pronged approach, he studies normal human and animal model brain patterning to diseases in which language and social communication are disrupted, such as autism. His laboratory has forged important collaborations with investigators to use evolutionary comparisons to further the genetic evaluation of human brain development and patterning, including work with songbirds and non-human primates. He also provides scientific oversight for Autism Genetic Resource Exchange (AGRE), the largest collection of multiplex autism families in the world.
Dr. Geschwind has published over a hundred papers and review articles and serves as an associate editor of the Neurobiology of Disease, deputy editor of Biological Psychiatry, and is an editorial board member of several other journals including Neuron. Dr. Geschwind is active on the scientific advisory boards of the March of Dimes, Cure Autism Now Foundation (now Autism Speaks), Faculty of 1000 Medicine, and the Society for Neuroscience Program Committee. In 2004, Dr. Geschwind received the Derek Denny-Brown Neurological Scholar Award from the American Neurological Association
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Oldham, M. C. Geschwind, D. H. Comparative genomics: grasping human transcriptome evolution: what does it all mean?.
Heredity.
2006; 96(5):
339-40.
Oldham, M. C. Geschwind, D. H. Deconstructing language by comparative gene expression: from neurobiology to microarray.
Genes Brain Behav.
2006; 5 Suppl 1:
54-63.
Lobo, M. K. Karsten, S. L. Gray, M. Geschwind, D. H. Yang, X. W. FACS-array profiling of striatal projection neuron subtypes in juvenile and adult mouse brains.
Nat Neurosci.
2006; 9(3):
443-52.
Chen, G. K. Kono, N. Geschwind, D. H. Cantor, R. M. Quantitative trait locus analysis of nonverbal communication in autism spectrum disorder.
Mol Psychiatry.
2006; 11(2):
214-20.
Ylisaukko-oja, T. Alarcon, M. Cantor, R. M. Auranen, M. Vanhala, R. Kempas, E. von Wendt, L. Jarvela, I. Geschwind, D. H. Peltonen, L. Search for autism loci by combined analysis of Autism Genetic Resource Exchange and Finnish families.
Ann Neurol.
2006; 59(1):
145-55.
Oldham, M. C. Geschwind, D. H. Evolutionary genetics: the human brain -- adaptation at many levels.
Eur J Hum Genet.
2005; 13(5):
520-2.
Alarcon, M. Yonan, A. L. Gilliam, T. C. Cantor, R. M. Geschwind, D. H. Quantitative genome scan and Ordered-Subsets Analysis of autism endophenotypes support language QTLs.
Mol Psychiatry.
2005; 10(8):
747-57.
Cantor, R. M. Kono, N. Duvall, J. A. Alvarez-Retuerto, A. Stone, J. L. Alarcon, M. Nelson, S. F. Geschwind, D. H. Replication of autism linkage: fine-mapping peak at 17q21.
Am J Hum Genet.
2005; 76(6):
1050-6.
Assal, F. Alarcon, M. Solomon, E. C. Masterman, D. Geschwind, D. H. Cummings, J. L. Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease.
Arch Neurol.
2004; 61(8):
1249-53.
Stone, J. L. Merriman, B. Cantor, R. M. Yonan, A. L. Gilliam, T. C. Geschwind, D. H. Nelson, S. F. Evidence for sex-specific risk alleles in autism spectrum disorder.
Am J Hum Genet.
2004; 75(6):
1117-23.
Geschwind, D. GENSAT: a genomic resource for neuroscience research.
Lancet Neurol.
2004; 3(2):
82.
Preuss, T. M. Caceres, M. Oldham, M. C. Geschwind, D. H. Human brain evolution: insights from microarrays.
Nat Rev Genet.
2004; 5(11):
850-60.
Yonan, A. L. Alarcon, M. Cheng, R. Magnusson, P. K. Spence, S. J. Palmer, A. A. Grunn, A. Juo, S. H. Terwilliger, J. D. Liu, J. Cantor, R. M. Geschwind, D. H. Gilliam, T. C. A genomewide screen of 345 families for autism-susceptibility loci.
Am J Hum Genet.
2003; 73(4):
886-97.
Geschwind, D. H. DNA microarrays: translation of the genome from laboratory to clinic.
Lancet Neurol.
2003; 2(5):
275-82.
Sobrido, M. J. Miller, B. L. Havlioglu, N. Zhukareva, V. Jiang, Z. Nasreddine, Z. S. Lee, V. M. Chow, T. W. Wilhelmsen, K. C. Cummings, J. L. Wu, J. Y. Geschwind, D. H. Novel tau polymorphisms, tau haplotypes, and splicing in familial and sporadic frontotemporal dementia.
Arch Neurol.
2003; 60(5):
698-702.
Alarcon M, Cantor RM, Liu J, Gilliam TC, the Autism Genetic Resource Exchange Consortium, Geschwind DH Evidence for a language quantitative trait locus on chromosome 7q in multiplex autism families..
Am. J. Human Genetics
2002; 70:
60-71.
Alarcon, M. Cantor, R. M. Liu, J. Gilliam, T. C. Geschwind, D. H. Evidence for a language quantitative trait locus on chromosome 7q in multiplex autism families.
Am J Hum Genet.
2002; 70(1):
60-71.
Sabatti, C. Karsten, S. L. Geschwind, D. H. Thresholding rules for recovering a sparse signal from microarray experiments.
Math Biosci.
2002; 176(1):
17-34.
Geschwind, D. H. Ou, J. Easterday, M. C. Dougherty, J. D. Jackson, R. L. Chen, Z. Antoine, H. Terskikh, A. Weissman, I. L. Nelson, S. F. Kornblum, H. I. A genetic analysis of neural progenitor differentiation.
Neuron.
2001; 29(2):
325-39.
Geschwind DH, Ou J, Easterday MC, Dougherty JD, Jackson RJ, Chen Z, Antoine H, Terskikh A, Weissman IL, Nelson SF, Kornblum HI A genetic analysis of neural progenitor differentiation..
Neuron
2001; 29:
325-339.
Liu, J. Nyholt, D. R. Magnussen, P. Parano, E. Pavone, P. Geschwind, D. Lord, C. Iversen, P. Hoh, J. Ott, J. Gilliam, T. C. A genomewide screen for autism susceptibility loci.
Am J Hum Genet.
2001; 69(2):
327-40.
Wilhelmsen, K. C. Miller, B. Geschwind, D. Commentary.
Neurobiol Aging.
2001; 22(1):
119-21.
Geschwind, D. H. Robidoux, J. Alarcon, M. Miller, B. L. Wilhelmsen, K. C. Cummings, J. L. Nasreddine, Z. S. Dementia and neurodevelopmental predisposition: cognitive dysfunction in presymptomatic subjects precedes dementia by decades in frontotemporal dementia.
Ann Neurol.
2001; 50(6):
741-6.
Kornblum, H. I. Geschwind, D. H. Molecular markers in CNS stem cell research: hitting a moving target.
Nat Rev Neurosci.
2001; 2(11):
843-6.
Geschwind, D. H. Sharing gene expression data: an array of options.
Nat Rev Neurosci.
2001; 2(6):
435-8.
Cholfin, J. A. Sobrido, M. J. Perlman, S. Pulst, S. M. Geschwind, D. H. The SCA12 mutation as a rare cause of spinocerebellar ataxia.
Arch Neurol.
2001; 58(11):
1833-5.
Geschwind, D. H. Sowinski, J. Lord, C. Iversen, P. Shestack, J. Jones, P. Ducat, L. Spence, S. J. The autism genetic resource exchange: a resource for the study of autism and related neuropsychiatric conditions.
Am J Hum Genet.
2001; 69(2):
463-6.
Kornblum, H. Geschwind, D. The use of representational difference analysis and cDNA microarrays in neural repair research.
Restor Neurol Neurosci.
2001; 18(2-3):
89-94.
Geschwind, D. H. Boone, K. B. Miller, B. L. Swerdloff, R. S. Neurobehavioral phenotype of Klinefelter syndrome.
Ment Retard Dev Disabil Res Rev.
2000; 6(2):
107-16.
Geschwind, D. H. Loginov, M. Stern, J. M. Identification of a locus on chromosome 14q for idiopathic basal ganglia calcification (Fahr disease).
Am J Hum Genet.
1999; 65(3):
764-72.
Wilhelmsen, K. C. Clark, L. N. Miller, B. L. Geschwind, D. H. Tau mutations in frontotemporal dementia.
Dement Geriatr Cogn Disord.
1999; 10 Suppl 1:
88-92.
Geschwind, D. H. Gregg, J. Boone, K. Karrim, J. Pawlikowska-Haddal, A. Rao, E. Ellison, J. Ciccodicola, A. D'Urso, M. Woods, R. Rappold, G. A. Swerdloff, R. Nelson, S. F. Klinefelter's syndrome as a model of anomalous cerebral laterality: testing gene dosage in the X chromosome pseudoautosomal region using a DNA microarray.
Dev Genet.
1998; 23(3):
215-29.
Geschwind, D. Karrim, J. Nelson, S. F. Miller, B. The apolipoprotein E epsilon4 allele is not a significant risk factor for frontotemporal dementia.
Ann Neurol.
1998; 44(1):
134-8.
Geschwind, D. H. Perlman, S. Figueroa, C. P. Treiman, L. J. Pulst, S. M. The prevalence and wide clinical spectrum of the spinocerebellar ataxia type 2 trinucleotide repeat in patients with autosomal dominant cerebellar ataxia.
Am J Hum Genet.
1997; 60(4):
842-50.
Geschwind, D. H. Rhee, R. Nelson, S. F. A biotinylated MutS fusion protein and its use in a rapid mutation screening technique.
Genet Anal.
1996; 13(4):
105-11.
Geschwind, D. H. Thormodsson, F. R. Hockfield, S. Changes in protein expression during neural development analyzed by two-dimensional gel electrophoresis.
Electrophoresis.
1996; 17(11):
1677-82.
Geschwind, D. H. Iacoboni, M. Mega, M. S. Zaidel, D. W. Cloughesy, T. Zaidel, E. Alien hand syndrome: interhemispheric motor disconnection due to a lesion in the midbody of the corpus callosum.
Neurology.
1995; 45(4):
802-8.
Minturn, J. E. Fryer, H. J. Geschwind, D. H. Hockfield, S. TOAD-64, a gene expressed early in neuronal differentiation in the rat, is related to unc-33, a C. elegans gene involved in axon outgrowth.
J Neurosci.
1995; 15(10):
6757-66.
Lidow, M. S. Goldman-Rakic, P. S. Gallager, D. W. Geschwind, D. H. Rakic, P. Distribution of major neurotransmitter receptors in the motor and somatosensory cortex of the rhesus monkey.
Neuroscience.
1989; 32(3):
609-27.
Geschwind, D. H. Hockfield, S. Identification of proteins that are developmentally regulated during early cerebral corticogenesis in the rat.
J Neurosci.
1989; 9(12):
4303-17.
Spence, S. J. Cantor, R. M. Chung, L. Kim, S. Geschwind, D. H. Alarcon, M. Stratification based on language-related endophenotypes in autism: Attempt to replicate reported linkage.
Am J Med Genet B Neuropsychiatr Genet.
2006;
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Groszer, M. Erickson, R. Scripture-Adams, D. D. Dougherty, J. D. Le Belle, J. Zack, J. A. Geschwind, D. H. Liu, X. Kornblum, H. I. Wu, H. PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry.
Proc Natl Acad Sci U S A.
2006; 103(1):
111-6.
Dougherty, J. D. Garcia, A. D. Nakano, I. Livingstone, M. Norris, B. Polakiewicz, R. Wexler, E. M. Sofroniew, M. V. Kornblum, H. I. Geschwind, D. H. PBK/TOPK, a proliferating neural progenitor-specific mitogen-activated protein kinase kinase.
J Neurosci.
2005; 25(46):
10773-85.
Nakano, I. Paucar, A. A. Bajpai, R. Dougherty, J. D. Zewail, A. Kelly, T. K. Kim, K. J. Ou, J. Groszer, M. Imura, T. Freije, W. A. Nelson, S. F. Sofroniew, M. V. Wu, H. Liu, X. Terskikh, A. V. Geschwind, D. H. Kornblum, H. I. Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation.
J Cell Biol.
2005; 170(3):
413-27.
Sun, T. Patoine, C. Abu-Khalil, A. Visvader, J. Sum, E. Cherry, T. J. Orkin, S. H. Geschwind, D. H. Walsh, C. A. Early asymmetry of gene transcription in embryonic human left and right cerebral cortex.
Science.
2005; 308(5729):
1794-8.
Karsten, S. L. Geschwind, D. H. Exercise your amyloid.
Cell.
2005; 120(5):
572-4.
Dougherty, J. D. Geschwind, D. H. Progress in realizing the promise of microarrays in systems neurobiology.
Neuron.
2005; 45(2):
183-5.
Oliveira, J. R. Spiteri, E. Sobrido, M. J. Hopfer, S. Klepper, J. Voit, T. Gilbert, J. Wszolek, Z. K. Calne, D. B. Stoessl, A. J. Hutton, M. Manyam, B. V. Boller, F. Baquero, M. Geschwind, D. H. Genetic heterogeneity in familial idiopathic basal ganglia calcification (Fahr disease).
Neurology.
2004; 63(11):
2165-7.
Abu-Khalil, A. Fu, L. Grove, E. A. Zecevic, N. Geschwind, D. H. Wnt genes define distinct boundaries in the developing human brain: implications for human forebrain patterning.
J Comp Neurol.
2004; 474(2):
276-88.
Jen, J. C. Chan, W. M. Bosley, T. M. Wan, J. Carr, J. R. Rub, U. Shattuck, D. Salamon, G. Kudo, L. C. Ou, J. Lin, D. D. Salih, M. A. Kansu, T. Al Dhalaan, H. Al Zayed, Z. MacDonald, D. B. Stigsby, B. Plaitakis, A. Dretakis, E. K. Gottlob, I. Pieh, C. Traboulsi, E. I. Wang, Q. Wang, L. Andrews, C. Yamada, K. Demer, J. L. Karim, S. Alger, J. R. Geschwind, D. H. Deller, T. Sicotte, N. L. Nelson, S. F. Baloh, R. W. Engle, E. C. Mutations in a human ROBO gene disrupt hindbrain axon pathway crossing and morphogenesis.
Science.
2004; 304(5676):
1509-13.
Teramitsu, I. Kudo, L. C. London, S. E. Geschwind, D. H. White, S. A. Parallel FoxP1 and FoxP2 expression in songbird and human brain predicts functional interaction.
J Neurosci.
2004; 24(13):
3152-63.
Bragin, A. Karsten, S. L. Almajano, J. Wilson, C. L. Geschwind, D. H. Engel, J., Jr. Large-scale microarray gene expression analysis in discrete electrophysiologically identified neuronal clusters.
J Neurosci Methods.
2004; 133(1-2):
49-55.
Hedlund, E. Karsten, S. L. Kudo, L. Geschwind, D. H. Carpenter, E. M. Identification of a Hoxd10-regulated transcriptional network and combinatorial interactions with Hoxa10 during spinal cord development.
J Neurosci Res.
2004; 75(3):
307-19.
Easterday, M. C. Dougherty, J. D. Jackson, R. L. Ou, J. Nakano, I. Paucar, A. A. Roobini, B. Dianati, M. Irvin, D. K. Weissman, I. L. Terskikh, A. V. Geschwind, D. H. Kornblum, H. I. Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations.
Dev Biol.
2003; 264(2):
309-22.
Hemmati, H. D. Nakano, I. Lazareff, J. A. Masterman-Smith, M. Geschwind, D. H. Bronner-Fraser, M. Kornblum, H. I. Cancerous stem cells can arise from pediatric brain tumors.
Proc Natl Acad Sci U S A.
2003; 100(25):
15178-83.
Geschwind, D. H. Tau phosphorylation, tangles, and neurodegeneration: the chicken or the egg?.
Neuron.
2003; 40(3):
457-60.
Caceres, M. Lachuer, J. Zapala, M. A. Redmond, J. C. Kudo, L. Geschwind, D. H. Lockhart, D. J. Preuss, T. M. Barlow, C. Elevated gene expression levels distinguish human from non-human primate brains.
Proc Natl Acad Sci U S A.
2003; 100(22):
13030-5.
Karsten, S. L. Kudo, L. C. Jackson, R. Sabatti, C. Kornblum, H. I. Geschwind, D. H. Global analysis of gene expression in neural progenitors reveals specific cell-cycle, signaling, and metabolic networks.
Dev Biol.
2003; 261(1):
165-82.
Compton, P. Geschwind, D. H. Alarcon, M. Association between human mu-opioid receptor gene polymorphism, pain tolerance, and opioid addiction.
Am J Med Genet B Neuropsychiatr Genet.
2003; 121(1):
76-82.
Fu, L. Abu-Khalil, A. Morrison, R. S. Geschwind, D. H. Kornblum, H. I. Expression patterns of epidermal growth factor receptor and fibroblast growth factor receptor 1 mRNA in fetal human brain.
J Comp Neurol.
2003; 462(2):
265-73.
Sobrido, M. J. Abu-Khalil, A. Weintraub, S. Johnson, N. Quinn, B. Cummings, J. L. Mesulam, M. M. Geschwind, D. H. Possible association of the tau H1/H1 genotype with primary progressive aphasia.
Neurology.
2003; 60(5):
862-4.
Schaffer, B. Wiedau-Pazos, M. Geschwind, D. H. Gene structure and alternative splicing of glycogen synthase kinase 3 beta (GSK-3beta) in neural and non-neural tissues.
Gene.
2003; 302(1-2):
73-81.
Jackson, G. R. Wiedau-Pazos, M. Sang, T. K. Wagle, N. Brown, C. A. Massachi, S. Geschwind, D. H. Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila.
Neuron.
2002; 34(4):
509-19.
Jackson, GR Wiedau-Pazos, M Sang, TK Wagle, N Brown, CA Massachi, S Geschwind, DH Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila..
Neuron. .
2002; 34(4):
509-19.
Geschwind, D. H. Miller, B. L. DeCarli, C. Carmelli, D. Heritability of lobar brain volumes in twins supports genetic models of cerebral laterality and handedness.
Proc Natl Acad Sci U S A.
2002; 99(5):
3176-81.
Karsten, S. L. Van Deerlin, V. M. Sabatti, C. Gill, L. H. Geschwind, D. H. An evaluation of tyramide signal amplification and archived fixed and frozen tissue in microarray gene expression analysis.
Nucleic Acids Res.
2002; 30(2):
E4.
Sobrido, M. J. Cholfin, J. A. Perlman, S. Pulst, S. M. Geschwind, D. H. SCA8 repeat expansions in ataxia: a controversial association.
Neurology.
2001; 57(7):
1310-2.
Geschwind, D. H. Miller, B. L. Molecular approaches to cerebral laterality: development and neurodegeneration.
Am J Med Genet.
2001; 101(4):
370-81.
Terskikh, A. V. Easterday, M. C. Li, L. Hood, L. Kornblum, H. I. Geschwind, D. H. Weissman, I. L. From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs.
Proc Natl Acad Sci U S A.
2001; 98(14):
7934-9.
Geschwind, D. H. Mice, microarrays, and the genetic diversity of the brain.
Proc Natl Acad Sci U S A.
2000; 97(20):
10676-8.
Geschwind, D. H. Founders and CAG repeats: cause or effect?.
Neurology.
1999; 52(4):
685-6.
Hong, M. Zhukareva, V. Vogelsberg-Ragaglia, V. Wszolek, Z. Reed, L. Miller, B. I. Geschwind, D. H. Bird, T. D. McKeel, D. Goate, A. Morris, J. C. Wilhelmsen, K. C. Schellenberg, G. D. Trojanowski, J. Q. Lee, V. M. Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.
Science.
1998; 282(5395):
1914-7.
Clark, L. N. Poorkaj, P. Wszolek, Z. Geschwind, D. H. Nasreddine, Z. S. Miller, B. Li, D. Payami, H. Awert, F. Markopoulou, K. Andreadis, A. D'Souza, I. Lee, V. M. Reed, L. Trojanowski, J. Q. Zhukareva, V. Bird, T. Schellenberg, G. Wilhelmsen, K. C. Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17.
Proc Natl Acad Sci U S A.
1998; 95(22):
13103-7.
Geschwind, D. H. Kelly, G. M. Fryer, H. Feeser-Bhatt, H. Hockfield, S. Identification and characterization of novel developmentally regulated proteins in rat spinal cord.
Brain Res Dev Brain Res.
1996; 97(1):
62-75.
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