Stem Cells, Pathways and Cancer:
From Biology to Therapy

Friday, March 3, 2006          8:45 am - 4:30 pm


UCLA Campus: DeNeve Auditorium at DeNeve Plaza
CEU Noncredit Program
Public Health 815 0.6 CEU

Faculty & Staff Enrollment: 0 dollars

Faculty & Staff Enrollment (BRN Credit): 25 dollars


Synopsis: A small population of cancer stem cells is critical for the development, maintenance and progression of cancer. These stem cells escape the traditional cancer therapies, leading to relapse and progression of the disease. Thus a deeper understanding of the role of stem cells in cancer is needed.

This symposium brings together internationally recognized experts from across the country, as well as within UCLA, to address some of the challenges raised by cancer stem cells. Critical issues underlying the biology of cancer stem cells are highlighted and new therapies that specifically target the pathways and genetic networks driving these cancer stem cells are discussed.

Sponsored by: The W. M. Keck Epithelial Cell Cancer Biology Program at UCLA, The UCLA Institute for Stem Cell Biology and Medicine, The UCLA Jonsson Comprehensive Cancer Center and UCLA Extension.

Coordinators: Paul Mischel, M.D., Associate Professor, Pathology and Laboratory Medicine, UCLA and Hong Wu, M.D., Ph.D., Professor, Molecular and Medical Pharmacology, UCLA

For more information call (310) 825-7093 or email: SHwang@uclaextension.edu

Click here for printable version

Program

8:00 Check-in and Refreshments
8:45-8:50 Introduction
Leonard H. Rome, Ph.D., Senior Associate Dean of Research, UCLA
8:50-9:00 Welcome and Opening Remarks
Paul Mischel, M.D., Associate Professor, Pathology and Laboratory Medicine, UCLA
Part I: Cancer Stem Cell Biology, Models, and Disease
9:00-9:45 Nuclear Cloning, Stem Cells, and the Reprogramming of the Genome
Keynote Speaker: Rudolf Jaenisch, M.D., Professor of Biology, Massachusetts Institute of Technology, Member, Whitehead Institute
9:45-10:15 PTEN, Stem Cells, and Cancer Stem Cells
Hong Wu, M.D., Ph.D., Professor, Molecular and Medical Pharmacology, UCLA
10:15-10:45 Stem/Progenitor Cells in the Etiology and Treatment of Breast Cancer
Jeffrey M. Rosen, M.D., Professor, Department of Molecular and Cellular Biology, Baylor College of Medicine
10:45-11:00 Break
11:00-11:30 Overlapping Neural Stem Cell and Brain Tumor Self-Renewal Pathways
Harley Kornblum, M.D., Ph.D., Associate Professor, Department of Molecular and Medical Pharmacology and Pediatrics; Director, Neural Stem Cell Research Center, UCLA
11:30-12:00 Prospective Identification of Human Brain Tumor Initiating Cells
Peter Dirks, M.D., Ph.D., Principal Investigator, Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto
12:00-1:00 Lunch Break
Part II: Cancer Stem Cell Pathways as Therapeutic Targets
1:00-1:30 Cancer Stem Cells: Lessons from Chronic Myeloid Leukemia
Charles Sawyers, Ph.D., Investigator, Howard Hughes Medical Institute, Hematology-Oncology, UCLA
1:30-2:00 Cancer Stem Cells and Personalized Medicine: Targeting Molecular Therapy for Glioblastoma
Paul Mischel, M.D., Associate Professor, Pathology and Laboratory Medicine, UCLA
2:00-2:30 Cancer Stem Cells: Lessons from Leukemia
John Dick, Ph.D., Canada Research Chair in Stem Cell Biology and Director, Program in Stem Cell Biology, Toronto General Research Institute, University Health Network; Department of Molecular and Medical Genetics, University of Toronto, Princess Margaret Hospital
2:30-2:45 Break
2:45-3:15 Leukemia Oncogenes and Leukemia Stem Cells
Gary Gilliland, M.D., Ph.D., Investigator, Howard Hughes Medical Institute; Department of Medicine, Brigham and Women’s Hospital, Boston
3:15-3:45 The Dark Side of Stem Cells
Michael F. Clarke M.D., Deputy Director, Stem and Regenerative Medicine Institute, Stanford University
3:45-4:30 Stem Cells and Leukemia Stem Cells
Keynote Speaker: Irving L. Weissman, M.D., Director, Institute for Cancer/Stem Cell Biology and Medicine, Professor of Pathology and Developmental Biology, Department of Pathology, Stanford University School of Medicine
4:30 Symposium Concludes

General Information:
Early registration is highly encouraged. Registration is limited and it is anticipated that this symposium will close early. To guarantee lunch and seating, you must pre-register as early as possible. Pre-registration will close by February 24, 2006. UCLA students, staff, and faculty may attend free of charge, but must pre-register and show a current valid UCLA BruinCard Photo ID at symposium check in.

A buffet luncheon will be served in the International Room at the upper level of Bradley International Hall.

Registration at the door subject to space availability. Please note that we anticipate no spaces will remain available by the date of this event.

Parking is available but limited in lot P7. All UCLA staff and faculty are encouraged to park in their designated lots and enjoy the walk to DeNeve Plaza in the northwest sector of UCLA. Click here for parking information and a campus map.

UCLA Extension is approved by the California Board of Registered Nursing (BRN), Provider Number BRN# CEP 11952. This symposium is approved for 6.0 contact hours.